Saturday, May 4, 2013

One third of patients seeking care for ischemic wounds die unhealed

These are the difficult numbers from Elgzyri and coworkers from our SALSAmigo Jan Apelqvist's group in Lund.

Outcome of Ischemic Foot Ulcer in Diabetic Patients Who Had no Invasive Vascular Intervention
Elgzyri T., Larsson J., Thörne J., Eriksson K.-F., Apelqvist J.

Eur. J. Vasc. Endovasc. Surg. 2013 [Article in Press]

Objective/background: There is limited information regarding outcome in patients not available for revascularisation. Our aim was to identify factors related to ulcer healing in diabetic patients with severe peripheral arterial disease who were not available for revascularisation.
Methods: Diabetic patients with a foot ulcer, consecutively presenting at a multidisciplinary foot centre with systolic toe pressure <45 all="" an="" ankle="" continuous="" death.="" excluded.="" follow-up="" had="" healing="" included.="" mmhg="" or="" p="" patients="" pressure="" prospectively="" received="" revascularisation="" until="" were="" who="">Results: Out of 602 patients (median age: 76 years) included in this study, 50% healed either primarily (76%) or with a minor amputation (24%). Seventeen percent of patients healed after major amputation and 33% died unhealed. By regression analysis, rest pain, impaired renal function, ischemic heart disease, cerebral vascular disease, extent of tissue destruction, and ankle pressure >50 mmHg affected the outcome of the ulcers.
Conclusion: Diabetic patients with ischemic foot ulcers not available for revascularisations are not excluded from healing without major amputation. Factors strongly related to outcome were co-morbidity, severity of peripheral arterial disease, and extent of tissue destruction. Our findings reinforce the need for a classification system considering these factors at decision-making for vascular intervention.