Friday, February 5, 2010

Pseudomonas Slows Maggots

From our colleagues in Denmark, courtesy of ScienceDaily:

Bacteria Toxic to Wound-Treating Maggots

ScienceDaily (Feb. 5, 2010) — Bacteria that infect chronic wounds can be deadly to maggot 'biosurgeons' used to treat the lesions, show researchers writing in the journal Microbiology. The findings could lead to more effective treatment of wounds and the development of novel antibiotics.

Scientists from the Copenhagen Wound Healing Centre, Statens Serum Institut and the University of Copenhagen in Denmark showed that maggots applied to simulated wounds heavily infected with the bacterium Pseudomonas aeruginosa, were unable to treat the wound and were left dead after 20 hours.

Chronic wounds, such as leg ulcers, affect 1% of the Western population and are painful and difficult to treat. Use of maggots to disinfect wounds is an ancient practice that regained popularity in the early 1990s. Maggot Debridement Therapy (MDT) is now a standard procedure at wound care centres all over the world, in which sterile larvae from the green bottle fly Lucilia sericata are applied to the wound either directly or contained within a sealed nylon bag. The maggots gently ingest necrotic (dead) tissue and kill ingested bacteria in the gut. In addition, the maggots secrete antimicrobial compounds into the wound, help reduce inflammation and promote wound healing. The actual biological mechanisms responsible for the process are still largely a mystery.

P. aeruginosa is an opportunistic bacterium responsible for many hospital-acquired infections. It is often associated with chronic wounds in which the bacteria clump together to form biofilms. By effectively talking to each other via a well-studied communication system called quorum sensing (QS), bacteria in biofilms are known to be more successful at avoiding destruction by the host immune system as well as antibiotics.

Dr Anders Schou Andersen, who led the research, explained that QS was also the key to P. aeruginosa's toxicity to maggots. "When we blocked the QS signalling pathways in the bacteria, the maggots were much better at surviving and potentially cleansing the wounds. Signalling between bacteria growing in biofilms is known to lead to the production of lethal toxins, without which the bacteria are more vulnerable to eradication."

Dr Andersen believes the research could benefit patients with persistent wounds. "MDT is generally very effective. It has been said that in a few cases MDT had failed, leaving the maggots dead in the lesion. We now think that this was probably due to the presence of P. aeruginosa in the wound," he said. "If we can find the specific bacterial mechanism that kills the maggots, we could target this when developing new treatments. For example, wounds infected with P. aeruginosacould be treated with an agent that interrupts bacterial signalling to ensure the success of maggot therapy and thereby wound healing."

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So the lesson: make sure to add vinegar before larvae...

Thursday, February 4, 2010

Wearable / Rentable Health Technologies: It's On in Japan

This post courtesy of CLEAR's Bijan Najafi:

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Wearable Health Monitoring Sensor Debuts in Japanese Market

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Jan 19, 2010 15:46Shinichi Kato, Tech-On!


In the service, Health-related information is collected and analyzed by a small sensor attached to a human body, and it is viewed and managed on a mobile phone or a PC. The company commercialized the health monitoring system, which is called "human recorder system," based on the research results of the Advanced Institute of Wearable Information Networks (WIN), a nonprofit organization established by researchers at the University of Tokyo. WIN is a group led by Kiyoshi Itao, professor emeritus at the university.WIN Human Recorder Co Ltd, a Japan-based venture firm, launched a health monitoring service that uses a sensor network.

The sensor is used to measure electrocardiographic signals, heart rate, brain waves, accelerated velocity, body temperature, respiration, pulse wave and so forth. WIN helped develop, for example, a program to analyze each data and determine health condition.

This time, WIN Human Recorder released the "HRS-I," a system that measures electrocardiographic signals, body surface temperature and human movements at the same time by attaching a sensor with wireless communication capability to the chest and determines health condition by using the software. Human movements are detected by a three-axis acceleration sensor.

The dimensions and weight of the sensor module are approximately 30 (L) x 30 (W) x 5mm (D) and 7g, respectively. Because of the small size and the light weight, the module does not give uncomfortable feeling when attached to a human body, the company said.

The sensor module has a 2.4GHz wireless communication function and can be continuously operated for three to four days with a CR2032 button battery. Because the obtained data can be wirelessly transmitted to a PC or a mobile phone, it is possible to monitor the health condition of an elderly person who lives alone in a remote place via the Internet.

For example, stress level can be measured based on the state of autonomic nerves determined from an electrocardiogram, and the fluctuation of heartbeat period can be analyzed.

The expected users of the HRS-I are companies that provide health monitoring services. The pricing of the service is more than ¥10,000 (approx US$111) per month for the rental of the software and more than ¥30,000 for the purchase of the sensor.

Marubeni Information Systems Co Ltd, a sales agent for the HRS-I, aims at sales of about ¥1 billion in a year after the release of the system and about ¥5 billion after three years.


SALSAism entry: Vaya con Dedos and Carpe Dedo

Two SALSAism entries courtesy of SALSA Fellow Tim Fisher:

Vaya con Dedos: A parting wish upon leaving the SALSA clinics or operating room. "Go with Toes" (rather than without)

Carpe Dedos: Sieze the Toe (while this may have come up before, Tim wanted to ensure it made the list).

For the complete running SALSAism list, click here.

Mob-Based Intelligence for Diabetes: Wired Magazine Says "Watch Harvard"

Harvard-Based Crowdsource Project Seeks New Diabetes Answers — & Questions

harvard_crowd

The medical establishment is about to get a dose of web 2.0-style medicine in the form of a crowdsourced, socially networked contest that opens the fight against Type 1 diabetes to the public at large — and to Harvard’s medical research departments — using InnoCentive’s online challenge platform for competition and collaboration.

The stakes are high, not only for the sufferers of Type 1 diabetes who stand to benefit from the leaps in research Harvard hopes the program will generate, but also for InnoCentive and Harvard researchers, who will likely see government funding extended if their findings prove helpful to diabetes sufferers, medical research in general, and our shared knowledge of how to share knowledge.

“Open innovation is an effective way to solve scientific problems in the business world,” said Harvard Business School assistant professor and co-leader on the project Karim R. Lakhani, Ph.D. “According to my research, innovation contests can help reveal and foster unexpected and novel solutions to vexing scientific problems.”

The Harvard Clinical and Translational Science Center’s first InnoCentive program divorces questions from answers, awarding prizes ranging from $2,500 to $10,000 to not only to experts who contribute the best answers but also to informed people outside the diabetes field or Harvard community who ask the best questions (submit ideas by March 1; subsequent contests will address other issues).

“There are all these people out there — they may teach 19th century English literature — but they’re smart and motivated and their kid has diabetes,” said Dr. Eva Guinan of the Dana-Farber Cancer Institute, director of Harvard Catalyst Linkages and co-leader of the project. “For years, they’ve watched their child do something, and they’ve had no place to ask the question, ‘Why isn’t somebody looking into this?’

“We want questions as well as answers, and we need to get them from a broader community because the same old people asking the same old questions in the same old way with slightly newer technology is not moving things fast enough or broadly enough for us to cope with these incredibly complicated diseases.”

To coin a medical analogy, if Harvard’s research community is a brain, it needs to form new neural connections between areas that had previously never been connected. Complicated problems can only be tackled by a complicated organizational brain. To date, most organizational brains are rudimentary and top-down rather constructed as a neural network, the way our more evolved brains are.

“That’s exactly right,” agreed Dr. Guinan. “People talk about the really distal nodes, which is just what you just described. It’s reaching into the formerly unconnected, or poorly connected, pockets of information and knowledge that are out there, that are otherwise not wired in…. The experimental question is: How do we do that in this environment, where knowledge is the coin of the realm.”

Dr. Guinan dreams that the contest will produce creative solutions, like one that kept her awake on Monday night: How about an iPhone app with a wireless connection to heat and pressure sensors in shoes that compensate for the loss of sensation in diabetics’ feet? When diabetic patients develop unfelt sores it can lead to amputation.

Need a new nerve pathway from the foot to the brain? There will be an app for that, if Harvard’s challenge realizes Guinan’s hopes for this crowdsourcing experiment.

Dwayne Spradlin, InnoCentive president and CEO, says the medical establishment has a lot to learn from the crowd and crowdsourcing — but perhaps even more from itself.

“Research today is often about publishing,” he said. “You might wait a year and a half for peer review, and that information is not yet being shared with other groups that would otherwise be doing derivative works. Tearing down those boundaries can do nothing but compress the rates at which we drive innovation through these systems, and it is desperately needed.”

Most of the funding for this effort comes from taxpayers, in the form of a National Institute of Health grant, with additional funding from the Harvard Catalyst Program, a Harvard-lead consortium of medical organization whose goal is to “remove the barriers and obstacles to cross-institutional collaboration.”

When the United States government funds a crowdsourced social network at the oldest university in the country to make medical research more effective, it’s hard to deny that the Obama administration is making good on at least part of its pledge to bring the government and the institutions in line with the latest technology.

One reason the NIH is funding this crowdsourcing experiment is the hope that its findings will stretch subsequent research dollars further. “Focusing across teams on solving very specific, well-defined problems could crack the code on collaboration and improve the yield of all of this medical research,” said Spradlin.

But in order for this government-funded crowdsourcing experiment to work, it will have to balance seemingly oppositional forces of competition and collaboration, especially because researchers tend to work in secret in order to edge out fierce competition for corporate funding and professorships.

But medical researchers, especially young ones, have ample incentive to participate despite research’s tradition of information control. The contest offers them a chance for them to earn their stripes on the fast track. Rather than filtering their ideas through the normal chain of command, or keeping their head down focused on a few specific micro-problems for their lab, they gain access to the big questions — and full credit for answering them.

And not only are younger researchers more comfortable with online tools like InnoCentive, says Dr. Guinan, but they have a different take on the line between public and private personae that makes them liable to share and exhibit a herd mentality that makes them more likely collaborators.

“I think that younger generations will embrace these things more,” said Dr. Guinan. “The walls about what they do and don’t share is very low, and the degree to which they move as a herd is unbelievable … and they’re used to information spreading much more rapidly. It’s much harder to hang onto information and have it be private.”

Apparently, what goes for teenagers socializing on Facebook and software engineers collaborating on a movie recommendation algorithm also goes for professional medical researchers. Social networks are often thought of as a frivolous waste of time, but they may not be so frivolous after all, should they lead to more efficient medical research that saves lives.



Read More http://www.wired.com/epicenter/2010/02/crowdsourcing-rewires-harvard-medical-researchers-brain/?intcid=inform_relatedContent#ixzz0eZgU6PXl

Wednesday, February 3, 2010

Heroes of Medicine: The $28 Foot

Thanks as always to good Professor Attinger from Georgetown for this find, written by Tim McGirk of Time Magazine:

Contentsred barHeroes of MedicineThe $28 Foot
Blk BarHeroes of Medicine
A Childs Pain
The Plant Hunter
In Search of Sight
A Dark Inheritance
Too Big a Heart
Seeing the Future
The Tumor War
The $28 foot
Drop Your Guns
The Wired Prairie
To Hell and Back
Beyond the Call
Bloodless Surgery
Rescue in Sudan
Physician Heal Thyself
blank
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An orthopedic surgeon who is a fellow of Britain's prestigious Royal College of Surgeons, Dr.Pramod Karan Sethi was working with his patients at Jaipur's Sawai Man Singh Hospital when he met scuptor Chandra for the first time

THE GLOBAL SCOURGE OF LAND MINES LEFT THOUSANDS LIMBLESS, AND THEN TWO GIFTED INDIANS DEVELOPED

The $28 Foot

BY TIM MCGIRK

People who live inside the world's many war zones, from Afghanistan to Rwanda, may never have heard of New York or Paris, but they are likely to know of a town in northern India called Jaipur. Jaipur is famous in strife-torn areas as the birthplace of an extraordinary prosthesis, or artificial limb, known as the Jaipur foot, that has revolutionized life for millions of land-mine amputees.

The beauty of the Jaipur foot is its lightness and mobility--those who wear it can run, climb trees and pedal bicycles--and its low price. While a prosthesis for a similar level of amputation can cost several thousand dollars in the U.S., the Jaipur foot costs only $28 in India. Sublimely low-tech, it is made of rubber (mostly), wood and aluminum and can be assembled with local materials. In Afghanistan craftsmen hammer the foot together out of spent artillery shells. In Cambodia, where roughly 1 out of every 380 people is a war amputee, part of the foot's rubber components are scavenged from truck tires.

The inventors of the Jaipur foot seem a mismatched pair. Dr. Pramod Karan Sethi, 70, an orthopedic surgeon, is a fellow of Britain's Royal College of Surgeons, while his collaborator, an artisan named Ram Chandra, reached only the fourth grade in Jaipur. Their paths first crossed more than 30 years ago at the Sawai Man Singh Hospital in Jaipur. There, Sethi was helping his orthopedic patients wobble down the corridor on their crutches, and Chandra was teaching lepers to make handicrafts.

Chandra is a kind of Pygmalion: he can turn whatever piece of stone or gold he touches into a lifelike creation. Born into a family that had been master artisans for four generations, he quickly established himself as one of Jaipur's finest sculptors, and his talents were sought by temple priests and princes. "If all I saw was your nose, it would be enough for me to sculpt a likeness of your entire body," says Chandra, 75, whose folded hands are like a box of old wooden tools. "It's all to do with proportions. That is the way God has made men."

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Tuesday, February 2, 2010

Amputation Prevention Is Special Guest on NPR Fundraising Campaign

Armstrong at the NPR/Arizona Public Media Bureau

Podiatry and limb salvage were front and center yesterday during the annual spring fundraising drive at National Public Radio's Arizona Public Media Bureau. David G. Armstrong, Professor of Surgery and Director of the Southern Arizona Limb Salvage Alliance, hosted an hour of programming with both NPR and classical radio. "I think it is wonderful when we can play hookie from clinic for an hour and support media that supports us", noted Armstrong. "It also affords us to get the word out in depth-- beyond the soundbites-- about the importance of foot care and amputation prevention." This is Armstrong's second tour at NPR, following a very successful drive in October, 2009.



Friday, January 29, 2010

UMC surgeons first to perform new technique

Published on Friday, January 29, 2010

The first surgeons ever to perform a “micrografting skin expansion” were at University Medical Center.

Surgeons from the University of Arizona Department of Surgery Southern Arizona Limb Salvage Alliance performed the procedure on a diabetic foot wound.

Micrografting skin is not a new technique, but the procedure performed by David G. Armstrong, DPM, PhD, UA professor of surgery and Alliance director, and his vascular surgery team was the first ever using a technique made possible with a new device developed by Dr. Elof Eriksson, of Harvard University.

The procedure, designed to replace certain types of skin grafting, takes a much smaller amount of grafting than previously required.

“People in the past have had to mince up skin in a very inelegant fashion that took a lot of time and led to invariably unpredictable results,” Armstrong said. “This new ‘self-contained’ procedure should allow us to do these procedures in minor-procedure rooms and in outpatient clinics, as well as in the operating room. That is a significant step forward.”

The procedure involves taking a small skin specimen from the patient. Then, using a special device, the skin is finely minced and spread on the wound, covering the surface many times wider than the skin sample itself.

“In many cases, we can take a postage stamp-sized piece of skin and expand it to 10 or more times its previous area,” he said. “We’re excited to see what the potential of this new procedure brings our highest-risk patients.

Thursday, January 28, 2010

Barefoot Running? For people with diabetes and neuropathy, barefoot could equal no foot: UofA Surgeon

The latest craze in fitness- barefoot distance running- adopting techniques used for centuries by Native Americans and African athletes- has led to many people dramatically changing their exercise routines. For some, that is beneficial- but for people with diabetes, it could literally cost life and limb. "I don't think we can overstate this case", notes David G. Armstrong, Professor of Surgery and Director of the University of Arizona's Southern Arizona Limb Salvage Alliance (SALSA), "People with diabetes should not go barefoot." Armstrong, who directs the largest research and clinical group in the world dedicated to amputation prevention explains that "Over time, people with diabetes lose the gift of pain. This problem, called neuropathy, causes them to literally be able to wear a hole in their foot just as we might wear a hole in a stocking." That "hole" also known as a diabetic foot ulcer, is what leads to more than one million amputations performed every year, worldwide. But Armstrong notes that the goal is not to sit on the couch. "We very much want our patients to be active-- just protected. If you don't use it, you lose it, but if you don't protect it, you lose it too!"

Monday, January 25, 2010

From the New York Times: Are Fingersticks Passe'?

IN THE ONGOING DEBATE BETWEEN MICRO (EUGLYCEMIA) AND MACROVASCULAR (BLOOD PRESSURE) DISEASE PREVENTION, A NEW SALVO IN A CANADIAN STUDY IS DISCUSSED HERE IN THE NEW YORK TIMES.

Regimens: Questioning Benefit of Diabetes Test Strips

Published: January 18, 2010

People with Type 2 diabetes are often advised to use blood-glucose test strips to monitor their blood sugar levels, but a Canadian analysis has found that routine self-monitoring is not cost-effective for many patients: the strips can cost almost a dollar each, and they prevent comparatively few complications of diabetes.

The finding was part of an analysisthat prompted the Canadian Agency for Drugs and Technologies in Health to issue a nonbinding recommendation against routine self-monitoring for many Type 2 diabetics — those who do not take insulin.

Experts in the United States said more studies were needed, but they emphasized that glucose test strips, which are covered by insurance, could be helpful for adjusting diet, exercise and drug regimens.

In addition, they are recommended for Type 2 patients who take insulin or the drugs called sulfonylureas, which stimulate insulin production; those patients are at risk forhypoglycemia, or very low blood sugar.

But for other Type 2 patients, the test strips’ benefits fall off sharply.

Another Canadian study reported that more than 1,000 patients would need to use the strips regularly to prevent a single case of kidney failure, for example, and about 500 would need to be treated to prevent a single stroke, amputation or case of blindness.

Rather than rely on test strips, Canadian experts said, patients need to be vigilant about their diet, exercise, weight and blood pressure.

“The message we’d like to impart to those living with Type 2 Diabetes,” said Barb Shea, vice president of the health agency, “is that it takes more than testing your blood to look after your health.”

Sunday, January 24, 2010

From the Times of London: Stone Age Amputations?

Evidence of Stone Age amputation forces rethink over history of surgery

Adam Sage (Paris)

The surgeon was dressed in a goat or sheep skin and used a sharpened stone to amputate the arm of his patient.

The operating theatre was not exactly Harley Street — more probably a wooden shelter — but the intervention was a success, and it has shed light on the medical talents of our Stone Age ancestors.

Scientists unearthed evidence of the surgery during work on an Early Neolithic tomb discovered at Buthiers-Boulancourt, about 40 miles (65km) south of Paris. They found that a remarkable degree of medical knowledge had been used to remove the left forearm of an elderly man about 6,900 years ago — suggesting that the true Flintstones were more developed than previously thought.

The patient seems to have been anaesthetised, the conditions were aseptic, the cut was clean and the wound was treated, according to the French National Institute for Preventive Archaeological Research (Inrap).

The revelation could force a reassessment of the history of surgery, especially because researchers have recently reported signs of two other Neolithic amputations in Germany and the Czech Republic. It was known that Stone Age doctors performed trephinations, cutting through the skull, but not amputations. “The first European farmers were therefore capable of quite sophisticated surgical acts,” Inrap said. The discovery was made by Cécile Buquet-Marcon and Anaick Samzun, both archaeologists, and Philippe Charlier, a forensic scientist.

It followed research on the tomb of an elderly man who lived in the Linearbandkeramik period, when European hunter-gatherers settled down to agriculture, stock-breeding and pottery. The patient was important: his grave was 2m (6.5ft) long — bigger than most — and contained a schist axe, a flint pick and the remains of a young animal, which are evidence of high status.

The most intriguing aspect, however, was the absence of forearm and hand bones. A battery of biological, radiological and other tests showed that the humerus bone had been cut above the trochlea indent at the end “in an intentional and successful amputation”. Mrs Buquet-Marcon said that the patient, who is likely to have been a warrior, might have damaged his arm in a fall, animal attack or battle.

“I don’t think you could say that those who carried out the operation were doctors in the modern sense that they did only that, but they obviously had medical knowledge,” she said.

A flintstone almost certainly served as a scalpel. Mrs Buquet-Marcon said that pain-killing plants were likely to have been used, perhaps the hallucinogenic Datura. “We don’t know for sure, but they would have had to find some way of keeping him still during the operation,” she said.

Other plants, possibly sage, were probably used to clean the wound. “The macroscopic examination has not revealed any infection in contact with this amputation, suggesting that it was conducted in relatively aseptic conditions,” said the scientists in an article for the journal Antiquity.

The patient survived the operation and, although he suffered from osteoarthritis, he lived for months, perhaps years, afterwards, tests revealed. Despite the loss of his forearm, the contents of his grave showed that he remained part of the community. “His disability did not exclude him from the group,” the researchers said.

The discovery demonstrates that advanced medical knowledge and complex social rules were present in Europe in about 4900BC, and that major surgery was likely to have been more common than we realised, Mrs Buquet-Marcon said.

Thursday, January 21, 2010

No More Help with X-Rays While Scrubbed? Apple's Answer to 3D

From Medgadget:

Intuitive 3D Interface May Be Perfect for Clinical Use

Last month Apple received a patent for a new 3D interface for manipulating objects on computer screens. Houston Neal at the Medical Software Advice blog suggests the new technology should be particularly useful for working with clinical images. Essentially, the 3D technology uses a computer camera to look at the movement of hands or head of the user to transform objects on the screen. Here's a short demo of the basic functionality:

Because of the intuitive nature of this interface and that it does not require touching any physical controls, this may turn out to be popular with radiologists and physicians using intraoperative imaging modalities while scrubbed up.

Wednesday, January 20, 2010

Shear Madness: From Lower Extremity Review

Beyond Plantar Pressure

by Cary Groner

Clinicians have known for many years that uneven plantar pressures, combined with the loss of sensitivity caused by peripheral neuropathy, are associated with foot ulcers in diabetes patients. Ulcers often occur in different areas than peak pressures do, however. Shear forces, caused by pressure differentials in the foot, may be more to blame than plantar pressures per se.

Shear is notoriously hard to measure, though, and researchers don’t always agree on how to define it. But better understanding of these forces may lead to improved prevention and treatment of ulcers and their grim sequelae, such as osteomyelitis and amputation.

“We can create a topographical map of vertical pressure on the foot, but shear stresses don’t always correlate with vertical stresses,” said David Armstrong, DPM, PhD. Armstrong is a professor of surgery at the University of Arizona College of Medicine. “It’s the equivalent of podiatric dark matter: we believe it’s important but we can’t measure it well. In fact, shear stress is probably more important than vertical stress because it occurs twice per step instead of once.”

According to Armstrong, plantar pressure offloading is a zero-sum game, because relieving pressure in one area increases it in others. As long as that additional pressure remains below a certain threshold, which is unique to each patient, the risk of ulceration drops and the potential for healing increases.

Michael J. Mueller, PT, PhD, a professor of physical therapy at Washington University in St. Louis, has done research suggesting that pressure gradients in the foot contribute to shear forces. As a result, he defines shear differently than some clinicians do.

“We’ve always considered shear as parallel to the surface of the foot, but our research shows forces perpendicular to the skin, just as pressure variables are,” he said. “If you have high stress in one location in the foot, and low stress in an adjacent location, that generates vertical shear. This reinforces, from a clinical standpoint, the need for even pressure distribution.”

This perspective helps explain why clinicians see more skin breakdown at the forefoot than at the heel, even though there is typically more pressure at the heel, Mueller added.

Georgeanne Botek, DPM, medical director of the diabetic foot program at the Cleveland Clinic, concurs with these perspectives.

“When it comes to shearing, most of what we see isn’t necessarily on the most weight-bearing surface,” she said. “I have several patients who have more of a lateral or plantar-lateral skin breakdown, which indicates it is more related to shear than to plantar pressure.”

According to Botek, the phenomenon also occurs frequently at the hallux–interphalangeal joint, where significant potential shearing occurs.

“That’s the plantar-medial aspect of the foot, where there tends to be extra friction and pressure, and that’s where we see changes in the skin—thickening, hardening, and subsequent hemorrhaging,” she said.

Clinicians should be attentive to the potential for such problems in diabetes patients with complications, Botek emphasized.

“Once we have a diagnosis of peripheral neuropathy, it raises a red flag,” she said.

Even if the underlying concepts remain incompletely understood, insights regarding the significance of shear forces offer hope for better orthotic management of at-risk feet.

“You need to devise an orthotic that focuses on equal distribution of the stresses,” Mueller said.

The others agree. Armstrong is on the scientific advisory board of a company that has commercialized an insole that purports to reduce shear, and Botek has her own approach.

“We try to look at the insole material, and the pattern of the foot imprint, then work with the pedorthist to come up with a top cover that may prevent shearing,” she said. “We also have to accommodate the foot more laterally. After all, bad doctors end up treating complications; mediocre doctors treat conditions; but great doctors prevent the problems in the first place.”

You can find all of its content online at www.lerresourceguide.com, with searchable listings and references that will take the experience to the next level.

Tuesday, January 19, 2010

SALSAism entry: Hammertosis Fugax

Our most recent SALSAism entry came by way of clinic today.

Hammertosis Fugax: A person with diabetes and blindness who develops a neuropathic wound on a contracted toe. This is not to be mistaken with Amaurosis Fugax, which is blindness due to transient retinal ischemia. The two may coexist, forming a dual fugue kind of oculodigital scenario.

Sunday, January 17, 2010

A Wii instead of a fancy gait laboratory?

Wii Balance Board Gives $18,000 Medical Device a Run For Its Money
Posted by timothy on Sunday January 17, @04:43PM

Gizmodo highlights a very cool repurposing effort for the Wii's Balance Board accessory. Rather than the specialized force platforms used to quantify patients' ability to balance after a trauma like stroke, doctors at University of Melbourne thought that a Balance Board might serve as well. Says the article: "When doctors disassembled the board, they found the accelerometers and strain gauges to be of 'excellent' quality. 'I was shocked given the price: it was an extremely impressive strain gauge set-up.'" Games controllers you'd expect to be durable and at least fairly accurate; what's surprising is just how much comparable, purpose-built devices cost. In this case, the Balance Board (just under $100) was compared favorably with a test platform that costs just a shade less than $18,000.

Vascular Surgery can Prevent Amputations

From our Colleagues in North India, where there are only six vascular surgeons regionally covering a population larger than the United States.

Rising incidence of diabetes and trauma cases because of road accidents would require many more vascular surgeons than there are presently in the country, as the super-specialty field of surgery could avert many amputations and help to reduce the health burden thus caused.
Interacting with the media Ravul Jindal, executive member Vascular Society of India (VSI) and head of Vascular and Endovascular Surgery at Fortis Hospital, Mohali said that the country lacked data on peripheral arterial disease (PAD) which inflicts legs and arms and if not treated in time fast develops into gangrene leading to amputations.
High prevalence of smoking and increasing population of diabetics have a direct bearing of vascular diseases of the extremities, he said. Other reasons causing the disease are old age, high cholesterol and hypertension, he added.
Risk factors result in blockade of blood vessels in leg resulting in loss of blood supply to foot with consequences such as infection, non healing ulcer and gangrene (blackening of toes).
Unfortunately these diseases are not diagnosed on time and patients ultimately land up with gangrene and consequent limb amputation,” Dr Jindal adding that absence of early diagnosis worsened the problem.
Its onset of peripheral gangrene that reveals absence of pulsations for long periods of time hitherto unnoticed. After diagnosis also only treatment of these cases has been amputations leaving primary vascular problem unsolved.
Lowering blood pressure, bad cholesterol levels, managing blood glucose and regular exercises are best ways to prevent these diseases.
In accident victims, where blood supply to limbs may have got damaged need repairing of the vascular system within 6 hours of the emergency, if the limb is to be saved. In Himachal where rate of grievous injuries per accident is very high, victims should be shifted to tertiary care institutions for timely intervention, said Jindal.
The doctor who had received advanced training in the specialty in UK, says no medical institution in India was offering advanced courses in vascular surgery, where in the developed world no hospital which handles emergencies could be run with a vascular surgeon on its staff.
He claimed that there were only about 65 vascular surgeons in the country of which there were only 6 in North India. There are too few of us to handle increasing numbers of patients with PAD and other vascular diseases, and awareness and preventive measures are needed, said Jindal.

Friday, January 15, 2010

FDA greenlights MediSens body area monitoring

from mobihealthnews.com

MediSensThe FDA recently approved MediSens Wireless’ wireless body monitoring system, which assesses muscle and neuromotor functions in the upper extremities, for its first phase of clinical trials. MediSens’ Clinical Movement Assessment System (CMAS) could be used by health care professionals working in physical medicine and rehabilitation, neurology, orthopedics and physical and occupational therapy.

One of MediSens’ technology’s key applications is to use the real-time wireless monitoring technology to help diabetic patients with peripheral neuropathy, which causes a loss of sensation in the foot, and other patients with health issues that affect their balance.

According to CMAS co-investor Reggie Edgerton, Ph.D., the technology could also potentially be used to help diagnose diseases states, including Parkinson’s disease.

With the FDA approval, MediSens plans to begin clinical trials, which could establish the efficacy of and cost savings from its technology’s deployment. The system will analyze fine motor movement, gross muscle strength, hand-eye coordination and patient response to treatment. The trials are planned across various centers, community hospitals, public health facilities and the Ronald Reagan UCLA Medical Center.

“We hope that this technology will help to reduce the large number of injuries caused by diabetic foot ulcers and by falls each year, both in hospital rehabilitation departments and in at-home care environments,” UCLA professor and MediSens co-founder Majid Sarrafzadeh said.

Sarrafzadeh is also a co-director of the Wireless Health Institute (WHI) at UCLA, which is dedicated to improving the timeliness and reach of health care through the development and application of wireless, network-enabled technologies integrated with current and next-generation medical enterprise computing. The WHI is under the executive direction of Dr. Patrick Soon-Shiong, a UCLA visiting professor of bioengineering and of microbiology, immunology and molecular genetics, whom MobiHealthNews interviewed soon after his recent appointment at WHI.

Monday, January 11, 2010

Shutting Off Cell Death: Perhaps It's not Just for Chemotherapy Anymore?

From the consistently spectacular Medgadget Blog.

Protectan Technology May Lead to Drugs That Mitigate Effects of Radiation Exposure


Cleveland Biolabs, a company out of St. Buffalo, NY, has received the first US patent for technology to make drugs to treat radiation exposure in mammals. The Protectan system utilizes flagellin protein to mess with the mechanisms of apoptotic cell death, specifically focusing on how those mechanisms differ between normal and tumor cells.

CBLB502 is a derivative of a microbial protein, which has demonstrated the capacity to reduce injury from acute stresses, such as radiation in animal models. CBLB502 mobilizes several cell protective mechanisms, including inhibition of programmed cell death (apoptosis), reduction of oxidative damage and induction of regeneration-promoting cytokines.
CBLB502 is being developed under the U.S. Food and Drug Administration's Animal Efficacy Rule to treat Acute Radiation Syndrome (ARS) or radiation poisoning from any exposure to radiation such as a nuclear or radiological weapon/ dirty bomb, or from a nuclear accident. This approval pathway requires demonstration of efficacy in representative animal models and safety and drug metabolism testing in healthy human volunteers.

Evidence of CBLB502's mechanism of action and activity in animal models was published in Science Magazine in April 2008 (Science, 2008, vol. 320, pp. 226-230). Data from 50 subjects in an initial Phase I safety and tolerability study indicated that CBLB502 was well tolerated and that normalized biomarker results corresponded to previously demonstrated activity in animal models of ARS. There is currently no FDA approved medical countermeasure to treat ARS.

CBLB502 is also being developed as a supportive care measure to reduce and prevent occurrence of side effects of radiotherapy or chemotherapy in cancer treatment.

Tuesday, January 5, 2010

From our colleagues at SUNY and Lubbock: Eavesdropping on Bacterial Conversations May Improve Chronic Wound Healing


ScienceDaily (Jan. 5, 2010) — Listening in on bacterial conversations could be the solution for improving chronic wound care, says a team of researchers at Binghamton University, State University of New York. Their findings have been published in the Journal of Applied Microbiology.

"Bacteria, often viewed as simplistic creatures, are in fact very sociable units of life," said Alex Rickard, assistant professor of biological sciences. "They can physically and chemically interact with one another and are quite selective about who they hang out with. How bacteria might communicate in chronic wounds, however, was somewhat of a mystery."

Working with researchers and physicians at the Center for Biofilm Engineering at Montana State University and the South West Regional Wound Care Center in Lubbock, Texas, Rickard and a team of undergraduate researchers were able to identify specific types of chronic wound bacteria and to test their ability to produce cell-cell signaling molecules.

Partial gene sequencing allowed the team to identify 46 chronic wound strains belonging to nine genera. Further research inferred that close to 70 percent of those chronic wound strains produce a specific type of communication molecule -- autoinducer-2 (AI-2). A smaller percentage -- around 20 percent -- produce a different type of communication molecules that are called acyl-homoserine-lactones (AHLs). Scientists already know that structurally different bacterial cell-cell signaling molecules are able to mediate cell-cell communication, including A1-2 and AHLs.

"Based on our findings, we think that most resident species -- the 'good' bacteria that live on us and don't cause disease -- produce AI-2 while the pathogenic species typically produce AHLs," said Katelynn Manton, who was part of the undergraduate team and is now pursuing her doctorate. "And it didn't seem to matter what kind of chronic wound we looked at -- diabetic ulcers, vascular ulcers or environmentally induced chronic wounds. They all indicated a presence of possible AHLs or AI-2s."

For Randy Wolcott, director of the Southwest Regional Wound Care Center, a clearer understanding of how these bacteria function is particularly important. "AI-2's may be the best explanation why our commensal Coagulase Negative Staphylococci and other synergistically helpful bacteria are immensely beneficial to us when they reside in a normal skin environment," he said. "However, when they turn or are coerced to a dark side in a wound or infected medical device, they can cause so much devastation and death."

According to Rickard and his team, the typically pathogenic bacteria communicate in one language, the 'good' bacteria in another. The big question now is whether any of them are bilingual and can listen in on one another's 'conversations.' Being able to interpret -- or perhaps even guide -- these cell-cell signals may be important factors in how wound development could be influenced.

"Can we steer pathogenic bacteria away from what is, in essence, a 'mob' mentality and prevent them from communicating," said Rickard. "Or can we tell the mob to do one thing when they should in fact be doing something completely different?"

Manipulation of cell-cell signaling has the potential to be an effective strategy for wound healing, particularly in influencing 'bad' bacteria -which are particularly resistant to antimicrobials. Typical chronic wound bacteria such as Pseudomonas aeruginosa tend to have an entire repertoire of aggressive tactics that allow them to maintain a strong presence in chronic wounds. As a result, they are able to multiply rapidly, driving out the resident species and hampering wound healing.

"When bacteria form biofilms, as they do in chronic wounds, they become protected from killing by antimicrobial agents," said Phil Stewart, director of the Center for Biofilm Engineering at Montana State University. "Topical antiseptics, systemic antibiotics, and the body's own defenses are unable to clear these infections. We need alternative strategies -- such as jamming bacterial communication -- to help weaken the biofilm defenses. Listening in on the bacterial signals may also provide a way to diagnose the state of a chronic wound."

Funded by two grants from the National Institutes of Health, Rickard is hoping to expand the study.

"I have been very fortunate to have access to a terrific range of top-notch undergraduate researchers here at Binghamton University," said Rickard. "And I will be tapping in to this resource yet again when we tackle the next phase of this project. Our goal is to include a wider range of wound types and compare the types of signals present. By doing this, we expect to be able to develop novel methods to monitor wound healing and ultimately prevent the establishment of chronic wounds."

Tuesday, December 29, 2009

Increase in diabetes patients having limbs amputated

From the UK Daily Telegraph
Doctors have reported a dramatic rise in the number of diabetic patients having limbs amputated.

Published: 4:44AM GMT 29 Dec 2009

The increase in amputations has almost doubled over a 10 year period with up to 100 patients a week losing a leg to complications of diabetes Photo: GETTY
The increase in amputations has almost doubled over a 10 year period with up to 100 patients a week losing a leg to complications of the disease.
The number of people diagnosed with type-two diabetes the type caused by obesity - has increased greatly in the past decade, which could partly explain the findings, according to researchers.

But doctors believe that with better care up to 80 per cent of amputations could be avoided.
Major amputations, above the ankle joint, have risen by 43 per cent and the average age of those having above-ankle amputations fell from 71 to 69 years, which followed the pattern of more people being diagnosed younger.
Dr Eszter Vamos, from Londons Imperial College, who led the study, said they had expected to see long-term complications of diabetes rising because the number of people diagnosed with the condition had increased.
"But at the same time there is very strong evidence that you can prevent up to 80 per cent of the amputations.
Along with complications such as heart attacks and strokes, people with diabetes are far more likely to develop foot problems, including ulcers, which can become infected and lead to gangrene.
Researchers believe that better checks by doctors and awareness of symptoms by patients could reduce the need for amputation.
The findings in the journal Diabetes Research and Clinical Practice - highlight the importance of frequent foot checks and getting control of blood sugar levels, blood pressure and cholesterol."
Diabetes UK said more early diagnosis was needed, as diabetes could go undetected for more than 10 years and most people already had complications when they were diagnosed.
The charity also said too many people with diabetes are walking barefoot around their houses.
It warned that diabetes sufferers are at risk of damage to their feet caused by them being numb, a complication of the disease.
Damage can lead to foot ulcers and slow- healing wounds which, if they become infected, can result in amputation.
Podiatrists recommend that people with diabetes should always wear slippers around the home to reduce the risk of foot injuries.
Caroline Butler, care adviser at Diabetes UK, said: "It's appalling that thousands of people with diabetes in the UK undergo lower limb amputations every year. We want to help reduce that number by getting people with diabetes to wear suitable slippers at home.

Donate Chips to the SALSA bowl- Save A Leg and Change a Life

In this season of giving, we have had many requests for donations to our SALSA foundation, whose proceeds go to fostering research in amputation prevention and healing. If you are interested, you can make your gift quickly and easily by clicking here.

If you've any specific questions regarding the SALSA foundation, please contact our Director of Development, Kari Schlachtenhaufen, JD at: karis@surgery.arizona.edu.

Sunday, December 27, 2009

Can you touch your toes? New Measure for Cardiac/Vascular Risk

Phys Ed: Can Touching Your Toes Test Your Arteries?
By GRETCHEN REYNOLDS (New York Times)


For years, cardiologists were aware that heart attacks are more common during the winter months than in any other season. Most assumed that the cause was cold weather. But then researchers in California examined death certificates in Los Angeles County, an area not known for its inclement winters, and found that, even there, fatal heart attacks spiked during the winter months. More specifically, they started rising around Thanksgiving, climbed inexorably through Christmas and peaked on New Year’s Day. A subsequent study of death certificates nationwide, published in Circulation in 2004, confirmed the association between the two holidays and heart-attack deaths. It was accompanied by a cheery editorial headlined “The ‘Merry Christmas Coronary’ and ‘Happy New Year Heart Attack’ Phenomenon.”


Why the number of heart-attack deaths should surge so significantly during the holidays still is not clear, although cardiologists have some well-founded guesses. “We suspect there is often an inappropriate delay in seeking medical attention” at this time of year, says Dr. Robert A. Kloner, a professor of medicine at the University of Southern California, a cardiologist at Good Samaritan Hospital and the lead author of both the 2004 study of deaths in Los Angeles County and the accompanying editorial. “People ignore the pain in their chest,” perhaps because they don’t wish to disrupt the festivities or they misinterpret the ache as overindulgence, Dr. Kloner says. By the time they get to an emergency room, it’s too late to save them. Stress and tension likely play a role, too. “Spending time with family members can be trying,” he says. “And there are often concerns about financial issues, buying presents and so on.” Even a wood-burning fireplace, a romantic symbol of wintry, holiday evenings, could be a contributing factor, because particulate matter in the air has been connected to an increase in the risk of heart attacks, Dr. Kloner says.

A provocative new study published this year in the journal Heart and Circulatory Physiology suggests, however, that there may be a novel way to test at least one element of your heart’s health right in your own living room, right in the middle of the holidays. Sit on the floor with your legs stretched straight out in front of you, toes pointing up. Reach forward from the hips. Are you flexible enough to touch your toes? If so, then your cardiac arteries probably are also flexible.

In the study’s experiment, scientists from the University of North Texas and several Japanese universities recruited 526 healthy adults between the ages of 20 and 83 and had them perform the basic sit-and-reach test described above, although their extensions were measured precisely with digital devices. Taking into account age and gender, researchers then sorted the subjects into either the high-flexibility group or the poor-flexibility group.

Next, using blood-pressure cuffs at each person’s ankles and arms, researchers estimated how flexible their arteries were. Cardiac artery flexibility is one of the less familiar elements of heart health. Supple arterial walls allow the blood to move freely through the body. Stiff arteries require the heart to work much harder to force blood through the unyielding vessels and over time could, according to Kenta Yamamoto, a researcher at North Texas and lead author of the study, contribute to a greater risk for heart attack and stroke.

What the researchers found was a clear correlation between inflexible bodies and inflexible arteries in subjects older than 40. Adults with poor results on the sit-and-reach test also tended to have relatively high readings of arterial stiffness. In short, the study concluded that “a less flexible body indicates arterial stiffening, especially in middle-aged and older adults.” No such correlation was found in those under 40, even when gender and fitness were considered as factors.
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These results do not mean, of course, that people in the inflexible group were in imminent danger of a heart attack on Christmas Day. Arterial stiffening does not indicate or inevitably lead to arterial disease, Mr. Yamamoto emphasizes. In fact, some degree of arterial stiffening is inevitable with age. But the stiffer your arteries are, the less efficient your heart.

How it is that stiff muscles in the back and legs are linked to stiff tissues near the heart is an issue that hasn’t been fully elucidated, Mr. Yamamoto says, although arterial walls are composed of the same kinds of elastic tissues as muscles elsewhere in the body. So it’s likely, he says, that alterations in the composition of muscle tissues in the lower back (including aging-related alterations in the amount of collagen within the muscles) could be occurring in the arterial walls at the same time.

What is surprising are some early indications that increasing your flexibility might somehow loosen up your arteries, too. That was the accidental and, as yet unreplicated finding of a small 2008 study at the University of Texas at Austin. The study was designed to examine whether weight lifting increased arterial stiffness. (It didn’t, at least on this occasion.) The control group consisted of people who stretched. They were not expected to show any change in cardiac function, but over the course of 13 weeks they in fact increased the pliability of their arteries by more than 20 percent.

Mr. Yamamoto and his colleagues are currently conducting an ambitious study to determine just how and whether stretching directly affects the arteries. The results won’t be available for some time. Until then, Mr. Yamamoto says, it’s best to consider your flexibility (or lack thereof) as a marker of your probable arterial elasticity. “If you can touch your toes in the sit-and-reach test, your flexibility is good,” he says. If you can’t, you might consider talking to your cardiologist — although, remember, as Mr. Yamamoto points out, that tight arteries are not necessarily diseased arteries. They’re just less than ideally fit.

As for avoiding the “Merry Christmas Coronary,” Dr. Kloner’s advice is succinct: “Don’t ignore symptoms,” he says. Avoid overimbibing, too, and tamp down stress. If this requires turning down an invitation from a wheedling relative, you could always try explaining that your cardiologist would say that it’s for the best.

SALSA Toe and Flow Youtube Channel

We have had a long relationship with youtube, posting some educational videos there over the past several years. We've now formalized this with our SALSA Toe and Flow Channel. If there is anything you'd like to see-- or even anything you'd like us to post or link to, please let us know!

Friday, December 18, 2009

India's 1st Multinational Study Group Meeting on 'Diabetic Foot and Wound Healing'

Diabetes Research Centre, Central Leather Research Institute (CLRI) and Medical Council of India were organized a Multinational Study Group Meeting on 'Diabetic Foot and Wound Healing' at CLRI, Chennai from 12th to 13th December, 2009.

Mumbai, Maharashta, December 18, 2009 /India PRwire/ -- Diabetes Research Centre, Central Leather Research Institute (CLRI) and Medical Council of India were organized a Multinational Study Group Meeting on 'Diabetic Foot and Wound Healing' at CLRI, Chennai from 12th to 13th December, 2009. Eminent Doctors from all over the world addressed in this Multinational Study Group meeting which happened 1st time in India.

The Multinational Study Group Meeting was organized in association with Diabetes Research Centre (Organizer), Central Leather Research Institute (Co-Sponsor) and Medical Council of India (Co-Sponsor).

ndia's First Multinational Study Group Meeting on 'Diabetic Foot and Wound Healing' was inaugurated by Dr. David Armstrong, DPM, Ph.D., Professor of Surgery & Director, Southern Arizona Limb Salvage Alliance (SALSA), University of Arizona, College of Medicine, USA. released a CD about 'Preventing Diabetic Foot Amputations: A Multinational Approach" on this occasion.

Dr. Sharad Pendsey, (Organizing Chairman of this meeting) Director, Diabetes Clinic & Research Centre, Dhantoli, Nagpur, Prof. Dr. A.B. Mandal, Director, CLRI. Dr. Vijay Viswanathan, (Organizing Secretary of this meeting) Managing Director, MV Hospital for Diabetes & Diabetes Research Centre, Royapuram, Chennai, Dr. Anil Bhansali, (Organizing Vice Chairman of this meeting) Professor and Head, Department of Endocrinology, PGIMER, Chandigarh and delegates from India & Abroad were also present on the occasion.

Speaking about the conference Dr. Vijay Viswanathan, (Organizing Secretary of this meeting) Managing Director, MV Hospital for Diabetes & Diabetes Research Centre, Royapuram, Chennai said "We are happy to organize this Multinational Study Group Meeting on diabetic foot and wound healing. The objective of this study group was to combine the expertise from the developing and developed countries. 'Preventing Diabetic Foot Amputations' was the key theme of this meet. The major focus of this conference was to build bridges between experts working in the field of the diabetic foot in different parts of the World.

The main focus of the study was to encourage research in the field of diabetic foot, which is at present lacking in many of the countries. The first meeting of the study group with experts from different countries like India, USA, Hong Kong, Saudi Arabia, Tanzania, Bangladesh, South Korea and Japan highlighted all these issues and the speakers shared their experience on the management of the diabetic foot in their own countries".

More than 300 Doctors from all over the World were participated in this Multinational Study Group Meeting.

The major topics covered in these two days are 1) Current review of Diabetic Ulcer Wound Healing, 2) Toe Flow and Metabolic Know, covering the risk spectrum of vascular disease, 3) Characteristics of Diabetic Foot problems in Western Pacific Region, 4) Management modalities for diabetic foot, 5) Diagnosis and Principles of Management of Peripheral Vascular Diseases, 6) Diabetic Foot Clinic in Saudi Experience, 7) Surgical approach of treating diabetic foot infection - Bangladesh Experience and many more topics.


For more information, please contact:

Ridhi Juneja

Communications Executive (L) 40558924, (M) 98333 63497

Wednesday, December 16, 2009

Take a Walk: How Chicago, Arizona Researchers Use Cutting Edge Walking Sensors to Predict Outcome of Limb-Salvage Surgery in Diabetes



Take a Walk: How Chicago, Arizona Researchers Use Cutting Edge Walking Sensors to Predict Outcome of Limb-Salvage Surgery in Diabetes

TUCSON, AZ. Researchers from Rosalind Franklin University of Medicine's Scholl College and the University of Arizona Department of Surgery's Southern Arizona Limb Salvage Alliance (SALSA) have published a pilot project that could revolutionize the way reconstructive surgery is performed in people with diabetes. "In the past, surgery designed to heal wounds or reduce the risk for development of wounds in people with diabetes has been haphazard", noted David G. Armstrong, Professor of Surgery and SALSA's Director. "This study suggests strongly that we can work toward predicting success preoperatively." The study, which uses cutting-edge sensors that sample pressure points on the bottom of the foot while they walk, employs an entire new way of analyzing the data. "We can now learn from previous works and use sophisticated algorithms to see deformities and help the surgeon plan the procedure", added Dr. Bijan Najafi, Associate Professor at Rosalind Franklin University and the lead author on this study. Armstrong concluded that "We believe that all clinics may one day have sensors like this and we can go a long way toward reducing unnecessary amputations, which occur once every thirty seconds around the world"

Friday, December 11, 2009

"A Copenhagen Summit for the Diabetic Foot": Harkless, Armstrong Headline Major Multinational Meeting on "Climate Change" in the Diabetic Foot

Photograph (from Left):
Lawrence B. Harkless, Vijay Viswanathan, and David G. Armstrong tour
the MV hospital for Diabetes in Chennai

CHENNAI, (Tamil Nadu, India)/ Hundreds of physicians, surgeons and
scientists from across South Asia gathered in Chennai today for a
first-ever symposium focusing on the multinational needs of amputation
prevention in the developing world. "This meeting has been a
revelation-- it was a Copenhagen Summit for the Diabetic Foot", noted
David G. Armstrong, Professor of Surgery and Director of the Southern
Arizona Limb Salvage Alliance (SALSA) at the University of Arizona
College of Medicine, one of the keynote speakers at the symposium.
"Just as in discussions of climate change, care of diabetes in general
and the diabetic foot specifically may be very different in the
developing world when compared to more affluent nations." The
symposium included world renowned physician and surgeon lecturers from
Africa, Asia, and the United States. The other US invited lecturer,
Lawrence B. Harkless, Founding Dean of Western University College of
Podiatric Medicine summed it up. "We have to work together if we're
going to solve this problem. It is bigger than any one country or any
discipline." The symposium, taking place this weekend, was organized
by Professor Vijay Viswanathan, of the MV Hospital for Diabetes in
Chennai. It was preceded by a government-sponsored meeting focusing on
adapting international diabetic foot guidelines for the developing
world. "We're hoping for a Climate Change in how we focus on the
foot", noted Armstrong. "I think we're moving farther along in really
making a positive difference."



Tuesday, December 8, 2009

Smart Slippers: AT&T Moves into Medical Monitoring

From the great folks at Medgadget:

____________

AT&T's Excursion Into Medical Monitoring

Filed under: Informatics

In San Francisco, AT&T recently showcased some of their research into the use of wireless technology in various industries (we just hope this isn't detracting from their efforts for their mobile phone network, which needs work). A few of the new projects are medical in nature. In the following video Lusheng Ji of AT&T Labs Research profiles smart slippers that analyze how patients walk and a pill minder that keeps track of how people observe their medication regimen.

Neat stuff! But no word on what happens when the slippers wander into a dead zone, or when the pill-minder's calls to you are dropped.

Link: AT&T Labs Research

Monday, December 7, 2009

UA Surgeons First to Perform New Skin Grafting Procedure




Contact: Jo Marie Gellerman, (520) 626-7219 Dec. 7, 2009
EDITORS PLEASE NOTE: For patient interviews, please call Jo Marie Gellerman, (520) 626-7219.
TUCSON, Ariz. – Surgeons from the University of Arizona Department of Surgery Southern Arizona Limb Salvage Alliance (SALSA) performed a first-ever “micrografting skin expansion” procedure on a diabetic foot wound at University Medical Center last week. The procedure, designed to replace certain types of skin grafting, takes a much smaller amount of grafting than previously required.
The procedure involves taking a small skin specimen from the patient. Then, using a special device, the skin is finely minced and spread on the wound, covering the surface many times wider than the skin sample itself.

Micrografting skin is not a new technique, but the procedure performed by David G. Armstrong, DPM, PhD, UA professor of surgery and SALSA director, and his vascular surgery team was the first ever using a technique made possible with a new device developed by Elof Eriksson, MD, PhD, of Harvard University.
“People in the past have had to mince up skin in a very inelegant fashion that took a lot of time and led to invariably unpredictable results. This new ‘self-contained’ procedure should allow us to do these procedures in minor-procedure rooms and in outpatient clinics, as well as in the operating room. That is a significant step forward,” Dr. Armstrong explained.
“In many cases, we can take a postage stamp-sized piece of skin and expand it to 10 or more times its previous area,” he said. “We’re excited to see what the potential of this new procedure brings our highest-risk patients.
“Advances in wound care offer hope for patients who have acute and chronic wounds. We think this procedure could potentially help our patients with diabetes at high risk for amputation and also help many of our soldiers on the front lines who suffer devastating injuries,” Dr. Armstrong said.
# # #

SALSAism entry: Turf Toe

Submitted by one of our stellar surgery residents, Wynter Phoenix, MD:

Turf Toe: a referral to SALSA without a solid medical rationale

And from Joe and me: Missle Toe: a penetrating traumatic toe injury in a person with diabetes

Sunday, December 6, 2009

Armstrong Holiday Greetings

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"Pinging" the Wound? How intelligent dressings may be in the offing

We have worked for a long time (and have been interested even longer) with wireless/wearable technologies to create what we call a "personal health network". Some of our colleagues within the NHS in the UK may be taking this one step further:

_______________

Boffins’ innovative dressing to ‘revolutionise’ wound treatment

A three-year research project being led by Cranfield University is set to revolutionise the way in which wounds are monitored and treated by developing the world’s first ‘smart’ wound dressings.

It is aiming to embed wireless sensors into dressings so that clinicians can find out how the wound is healing without having to remove them. They will be tailored particularly towards treating diabetic ulcers, burns, lesions and pressure sores, and will use odour, moisture and temperature sensors to detect signs of infection and whether healing is taking place.

Readings can be taken from a hospital bed or from the patient’s home, reducing the need for hospital visits.

Professor Seamus Higson of Cranfield Health said: “Many dressings are replaced for no reason other than to inspect the wound. What is often needed is an early warning should intervention be needed.

“Our ‘smart’ dressing will register the state of the injury without having to remove the dressing, meaning less contact with infection and less disruption to the healing process.

“Some 80 per cent of the chronic wounds that don’t heal are related to diabetic conditions, with five per cent of the NHS budget being spent on wound healing.

“This project is very exciting as it has the potential to reduce the enormous amount of discomfort that wounds can bring, improve the healing process and, in some cases, the quality of life for patients. We hope this technology will be at the clinical trials stage within two years.”

Later in the project, Professor Higson will be working with Cranfield Health colleagues Professor Richard Aspinall and Dr Frank Davis to investigate the possibility of feeding cells into wounds to increase the speed of the healing process.

The project has received £1.5m of funding from the Technology Strategy Board and is being undertaken with the Wound Healing Institute at Cardiff University; Microarray, manufactures of micro-electrode arrays for use within chemical and biosensors; and Toumaz Technology, developers of wireless body monitoring technologies.

Saturday, December 5, 2009

Of Toes and Politics: Limb Salvage in Trinidad's Parliamentary Officials

Doctors amputate Ramnath’s toe

By Richardson Dhalai Friday, December 4 2009

click on pic to zoom in
Couva South MP Kelvin Ramnath....
Couva South MP Kelvin Ramnath....

In order to save his right leg, surgeons had to amputate a toe from the right foot of UNC Couva South MP Kelvin Ramnath last week.

Ramnath, who suffers from diabetes, sustained an injury to his foot three months ago and was receiving treatment, which included minor surgery and antibiotics, to aid in the recovery.

However, he said although the treatment seemed to be working, doctors later discovered that the bone had become infected and, to save his leg, doctors recommended amputation. “It was not very nice.

Lots of pain so I had the surgery done on November 23,” Ramnath told Newsday yesterday.

“I am still unable to wear shoes and slippers are not allowed in the Parliament Chamber but I should be able to attend Parliament next week,” he said.

Ramnath said House Speaker Barry Sinanan has been informed about his condition and “graciously granted” him an extension on his leave of absence from the Parliament.

His parliamentary colleagues have also been told about his illness and Opposition Leader Basdeo Panday and Princes Town North MP Subhas Panday have visited him at his home. Ramnath is presently undergoing hyperbaric oxygen therapy, which is used to treat diabetic illnesses such as diabetic foot, diabetic retinopathy, and diabetic nephropathy.

Hyperbaric oxygen therapy is the medical use of oxygen at a level higher than atmospheric pressure. Ramnath has so far received 33 treatments. Ramnath is not the only MP to have fallen ill due to diabetes. In 2007, former PNM Laventille West MP, Eulalie James, who is also diabetic, opted out of contesting the general elections, after her right leg was amputated following major surgery in Cuba.

Ramnath missed the 2010 Budget debate in September due to illness and was granted a leave of absence from the House of Representatives from October 9 to 30, as he underwent angioplasty surgery after doctors discovered blockages in the arteries of his heart. In spite of his health setbacks, Ramnath remains as feisty as ever and is once again backing Panday to retain the leadership of the UNC in the party’s elections on January 24, 2010. “The UNC is the most democratic party in the West Indies where anyone can contest any position that they want,” Ramnath said.

“But I am a Panday supporter because I believe that he has the moral authority to lead this party at this time notwithstanding the objection from the so-called dissident members. I believe that Mr Panday is the only one who can lead the party,” he said.

Thursday, December 3, 2009

"Not on My Watch": Preventing Hospital-Related Infections

Ms. Barbara Dunn of Kimberly-Clarke approached SALSA alumna Janice Clark today telling her about a new initiative of theirs designed to reduce hospital-acquired infections. We had a look at it and definitely believe it is worth a link.

Wednesday, December 2, 2009

Negative Pressure Wound Therapy and Materials: Unclogging The System?

While this is not a new discussion for us at SALSA, we thought it appropriate to get the discussion out into the ether.

For so very long, we have been asking why NPWT with foam works so well-- particularly when compared with certain types of gauze. Is there some magic property between the two? After all, a vacuum is a vacuum-- and the most perfect way to have a vacuum might be to have nothing in contact with the surface?!

We have thought that the main reason that foam- particularly polyurethane (PU) foam- works well is because it stays porous and provides channels for even distribution of NPWT and won't "clog up the line" with wound debris.

Perhaps this holds true when we discuss our concept of "wound chemotherapy" by way of streaming fluid through the wound. When we stream that fluid through the wound, we are unclogging channels in the PU foam. This most certainly must have a positive therapeutic effect. It also partly explains why we see a reduction in maceration and a reduction in slough in the wound.

Finally, this explains why we often don't frequently see this change in the wound with intermittent streaming (ie instilling fluid with a "hold" period in NPWT). This might not have the same hydrodynamic effect.

Anyway, we look forward to your feedback as always.



Tuesday, December 1, 2009

Message from Ron Jensen, APMA President: Make Amputation Prevention a Priority

Healthcare Business News
Ronald Jensen
Ronald Jensen

Make preventive care a priority

By Ronald Jensen
Posted: December 1, 2009 - 5:59 am EDT

Over the course of their career, medical professionals often make decisions that permanently affect the lives of their patients. For me, as a doctor of podiatric medicine, nothing is more tragic than sitting down with a patient to inform them that he or she will have no other choice than to have a toe, a foot or even their entire leg amputated due to blood flow complications from diabetes. The most frustrating part? This situation is one that typically could have been prevented—time and time again.

Amidst the wrangling over an agreeable healthcare reform solution, Americans are still trying to come to terms with reform's hefty price tag. For many, it is hard to imagine increasing funding for a healthcare system that has already proven to waste millions of dollars each year.

Advertisement | Your Ad Here





It has been widely publicized in the media that the U.S. spends more than twice on healthcare what other developed countries do—yet sees little return on this enormous investment. Lost in the media mix and debate of the issues is a fundamental principle that is not brought to the forefront of discussion often enough: prevention.

As president of the American Podiatric Medical Association, I believe that access to preventive care outweighs the effectiveness of some of medical technology's greatest triumphs. Daily, my colleagues and I are on the front lines of diabetes management. Without the doctors to catch a person's blood flow problems to their lower limbs before the onset of serious complications, even the most advanced technologies are of little use to successfully treat the condition.

Make no mistake, providing better preventive care for epidemics such as diabetes could help save our broken healthcare system billions of dollars every year. Diabetes is not only devastating to the entire body—it also hits the American healthcare system hard in the wallet, with direct and indirect costs reaching nearly $200 billion per year.

Nearly 24 million people—8% of the U.S. population—are currently battling diabetes. Treating the disease and its many complications requires a complete management team, including a podiatric physician, to attend to the necessary foot care those with diabetes require. However, diabetic complications are frequently seen by a medical professional only after the sole treatment option is total amputation of a toe, foot or lower limb.

Many of our nation's healthcare problems have evolved from a general lack of education. Studies have shown that simply creating greater public awareness of diabetic foot care could positively affect our healthcare system. According to an article published in the Journal of the American Podiatric Medical Association, comprehensive amputation prevention programs can reduce amputation rates from diabetic complications by as much as 70%.

Detecting diabetic foot ulcers early and staving off tragic foot and leg amputations benefits more than just the individual whose foot or leg is spared. The entirety of amputation costs avoided with prevention—including actual procedural costs, necessary hospital stay and follow-up care—can save our healthcare system up to $8 billion each year. Complications from diabetes—including diabetic ulcers and amputations—are preventable, but only with the help of a diabetes management team, which includes a podiatrist, vascular surgeon and primary-care physician.

Diagnosed cases of diabetes will continue to rise exponentially without an immediate intervention. Current statistics show that nearly 6 million Americans have diabetes and are not aware of their disease.

Something must be done to encourage both those with diabetes and those at risk to seek out the critical preventive care that will save their limbs and their life. I urge our lawmakers to make diabetes prevention—and preventive care for all major health conditions—a top-level priority in the healthcare reform debate. The short-term payoff may not be seen overnight. The long-term successes, however, will be monumental—helping to keep doctors like myself from having to present patients with a heart-breaking, life-altering diagnosis far too often.

Ronald Jensen, a physician, is president of the American Podiatric Medical Association. He resides and practices podiatry in Modesto, Calif.



What do you think? Post a comment on this article and share your opinion with other readers. Submit your comments to Modern Healthcare Online at mheditorial@modernhealthcare.com. Please be sure to include your hometown and state, along with your organization and title.

Monday, November 30, 2009

Wound Measurement via Phone

From our colleagues at MedGadget:

Remote Wound Management With Help of Smart Phones

Filed under: Telemedicine

Wound patients typically get lots of care at home, either from visiting nurses or from home care providers. Now technology is coming to even this forgotten medical market. And not surprisingly, it is mobile phone technology with backing from a big gun: AT&T. What we know is that the Wound Technology Network, a telehealth-based wound management service, is giving out HTC smart phones equipped with iVisit software to many of its providers for sending images back to specialists for remote analysis:

Under a two year agreement with AT&T, Wound Technology Network will equip its clinical staff including physicians, nurse practitioners and physician assistants across South Florida and Southern California with HTC FUZE™ smart mobile devices when providing care in patient’s homes. Clinical staff will use the devices to access an application developed by iVisit which creates videoconferencing tools for mobile devices and PCs and speak live with a wound care specialist at Wound Technology Network’s tele-health center who will assist them to assess the patients’ wounds and perform the necessary treatment. To aid in the treatment process, clinical staff will also capture images of the patient’s wounds using the HTC FUZE™ and transmit the images to the wound care specialists to upload onto an electronic medical record which is immediately faxed to the patient’s primary care physician.

SALSAism entry: ManifesTOE


Here is another addition to our list of SALSAisms from our very own stellar fellow, Tim Fisher.

ManifesTOE: An operative report following an amputation prevention procedure (bypass or incision and drainage or graft/flap.

Monday, November 23, 2009

Skin Bacteria and the "Microbiome"- Misanthropic microbial communities?

I have been speaking (electronically) with my colleague Randy Wolcott-- the very talented clinician and widely acknowledged biofilm guru from Lubbock. He was telling me of his experience at the American Society of Microbiology meeting in Mexico recently, where the discussion has continued to focus not on one bug, but on "biomes" of bugs.

The more we discuss this, the more we realize that the possibility of what we refer to (tongue in cheek) as an "H. pylori" for a wound may be a good analogy-- but a simplistic one. I will quote good Dr. Wolcott:

"While, H. pylori possesses all the tools necessary to attach, form a biofilm and create a hyperinflammatory environment on which it can subsist, many bacteria choose to co-aggregate to have all the elements necessary for biofilm formation and the ability to produce a chronic infection.
"...most of the biofilm experts agree that the presence of numerous different species existing in the same host niche (wound) was sufficient to strongly suggest that a biofilm was present. This is based on the laboratory finding that it is very rare for planktonic bacteria to coexist in the same area while biofilms are almost polymicrobial.
I like your phrase [David] “misanthropic microbial communities” because it connotes bacteria abandoning their commensal roles and have turned to the dark side of harming humanity. "

This is really interesting stuff. I am so very fascinated where we're going!


Centers for Disease Control Maps: Foot Exams and Self-Exams

Many of you may know this, but the United States Centers for Disease Control and Prevention is a veritable treasure trove of important information regarding diabetes care trends in the United States. To that end, we share with you the number of documented diabetic foot examinations by state in this post. Enjoy!

As a bonus, here is the link for documented patient self-foot-exams. We can do a lot better.



Wednesday, November 18, 2009

More SALSAisms

When the chips are down, you need SALSA

FreeToes and SALSA

Monday, November 16, 2009

"One Stop Shop" For Amputation Prevention

Here is a terrific article from the Daily Mail from our friend and colleague Prof. Mike Edmonds' world-class unit at King's College Hospital, London.

______________

Thousands of diabetics could be saved from needless amputation, claims 'one-stop shop' specialist

By DAVID HURST
Last updated at 1:02 AM on 17th November 2009


One of the great worries for diabetics is complications.

Nearly 800,000 are at risk of blindness, heart disease and kidney failure because their blood sugar levels are not under control, it was reported last weekend.

Every week 100 people lose a foot or limb through diabetes.

Test

The amount of amputations through diabetes could be reduced if patients were seen at a specialist centre, a specialist has claimed

But according to a leading specialist, much more could be done to reduce the numbers who have an amputation - if only patients were seen at a specialist centre.

Retired nurse Valerie Robinson was destined to be another of the unlucky ones.

Last year, an ulcer on her left ankle became so badly infected that doctors told her it was highly likely to become gangrenous. The leg would have to be amputated or she would die. 'I was absolutely devastated,' she recalls. 'I'd never thought it would come to this. It was very depressing.'

Foot ulcers - the result of nerve damage and poor blood flow - are a common problem for diabetics. The nerves control blood pressure. Damage to them causes reduced blood flow to the extremities, leading to a loss of sensation.

Poor blood flow means the skin does not regenerate as quickly and becomes thin and easily damaged. The feet are particularly vulnerable. Even something as apparently benign as a shoe that rubs can cause problems, as no pain is felt.

Left untreated, a sore can develop.

The lack of blood flow means the skin takes longer to heal and doesn't heal as well - often resulting in an ulcer and infection. Up to 15 per cent of patients with foot ulcers end up needing amputation.

As well as great personal misery, this costs the NHS £252 million a year.

Valerie Robinson

Diabetic Valerie Robinson was saved from having her leg amputated after seeing Dr Edmonds

But Valerie was spared drastic surgery thanks to the pioneering approach taken by Dr Mike Edmonds, a diabetes consultant at King's College Hospital in London. He runs what could be described as a one-stop shop for diabetics.

Unlike most hospitals, Dr Edmonds has a large team of experts, including orthopaedic surgeons, vascular surgeons, specialist nurses and chiropodists.

He believes that more than half of diabetic amputations could be avoided if all a patient's diabetic complications, from blocked arteries to bone problems, were treated, rather than just their feet.

'We're mainly a diabetic foot clinic, but we can also treat other damage caused by diabetes, such as kidney or heart failure,' he says.

'Our approach is different from most hospitals. The key is to ensure patients get speedy, aggressive treatment, provided by experts across a range of disciplines. As a result, we've managed to save the limbs of patients who were destined for an amputation.'

Valerie is typical of the patients Dr Edmonds sees. The retired nurse from Hastings, East Sussex, was diagnosed with type 2 diabetes in 1986.

'I knew, from being a nurse, how important it is for diabetics to look after their feet. I always wore shoes that fitted well. But two years ago I developed a condition called Charcot foot, where the bones in the feet soften and cause the foot to change shape.

'My left foot started getting flatter, and my ankle started to turn over unnaturally.

'Then, last year, I slipped and bruised my left foot, and just below my knee. I got the ulcer due to my bad circulation and the wound couldn't heal. I knew ulcers were bad news, so I went to my then local hospital in East London.'

There, to her horror, doctors told her she was at very high risk of gangrene. If her lower leg was not amputated, the infection could spread and kill her.

Then Valerie struck lucky. First, her leg did not become immediately gangrenous and, a few months later, during a check-up, one of her doctors mentioned King's College Hospital.

She asked to be sent there for a second opinion. Dr Edmonds and his team were confident her leg could be saved through a simple operation. 'I cried with relief when they told me,' she says.

The cause of Valerie's problems was the bone deformity, which made her vulnerable to falls and therefore ulcers. These kinds of bone deformities are common in diabetics because nerve damage causes the joints to deteriorate.

The nerve damage also means patients have little or no sensation, so they're less likely to notice when their feet are painful. It means they continue to walk and put pressure on the bones, making the injury worse.

Dr Edmonds explains: 'We're increasingly treating patients with "neuroischaemic feet" - that is, with both nerve damage and reduced blood supply.

'The main treatment is to improve the blood supply, either by opening up the artery in the leg with a balloon or stent, or performing a bypass around the blocked artery.'

Fortunately, Valerie still had a good enough blood supply to the leg, so rather than opening up the arteries, the team's orthopaedic surgeon corrected her misshapen foot to solve the problem for good. Valerie's ankle was straightened by the insertion of a special nail into the bones of the foot.

'Many hospitals think the sort of operation we did on Valerie is hazardous and doesn't work,' says Dr Edmonds.

'Working with the smaller arteries below the knee, including the foot, requires complex procedures which are not readily available to diabetic patients in most hospitals.'

But having a team ready to take an 'aggressive' approach to diabetic disease means this kind of option is possible at King's College Hospital.

clinic, which accepts referrals from around the country, sees between 20 to 35 patients every day and there are only about three amputations a year - ten times fewer than the national average.

'One lady came to us with severe gangrene in her big toe and an infection in the surrounding bone. She had blocked arteries in her lower leg and she'd been warned she might lose her leg.

'But the staff here performed an arterial bypass to her lower leg to save it. In the end, she lost only her toe.

'What makes our approach so successful is that we take a holistic approach,' says Dr Edmonds. 'Patients with an ulcer need their whole body treating, not just their foot.'

There are only a handful of other UK hospitals, including Ipswich, Edinburgh and Exeter, with anything close to a similar service.

'There should be teams such as our one at every hospital to help patients such as Valerie,' says Dr Edmonds.

Valerie knows how lucky she's been. 'I can't bend my ankle, and never will be able to - but my leg has been saved,' she says.

'I can stand and walk on my leg once again. Without the clinic, I'd be fitted with a prosthetic leg. It's a fantastic service.'

DIABETIC Foot Clinic, King's College Hospital, 020 3299 3223. Diabetes UK, 020 7424 1000, www.diabetes.org.uk



Read more: http://www.dailymail.co.uk/health/article-1228373/Thousands-diabetics-saved-needless-amputation-claims-stop-shop-specialist.html#ixzz0X5O2sJTs

Sunday, November 15, 2009

NASCAR and Diabetes: A Family Affair to Prevent Amputations

PHOENIX, Arizona. Jeff DeSantis, past President of the California Podiatric Medical Association and David G. Armstrong, Professor of Surgery and Director of the Southern Arizona Limb Salvage Alliance (SALSA) were pit-crew VIP's at the unveiling of the "Diabetes is A Family Affair" initiative supported by the American Podiatric Medical Association (APMA). "It is a privilege to be a part of this enormously important program in such a splendid venue like the Sprint NASCAR series", noted Professor Armstrong, "Nearly one in 5 of the population at this event will have diabetes and everyone here knows someone with the disease. What we need to tell them is that the problem is preventable-- and the most common of diabetic problems-- foot infections and amputations-- are even more preventable." The pair of podiatric leaders were guests of Hall of Fame Racing's number 96 Ask.com Ford, driven by Kevin Harvick. "We're grateful to Hall of Fame Racing's generosity and support and believe that this kind of program can do nothing but good to reduce the needless number of amputations in the USA and around the world."

Friday, November 13, 2009

Toemigo and Flowmigo

Two new self explanatory additions to the list of SALSAisms.

Wednesday, November 11, 2009

Are Diabetic Feet Less Cushy?

We at SALSA have been fascinated with a recent paper by our colleagues Hsu and coworkers from Chang Gung Memorial Hospital and National Taiwain University Hospital. Their evaluation of the plantar fat pad-- that specialized fat that exists on the sole of every one of us-- may undergo changes in people with diabetes. To make a long story short, fewer small "microchambers" of fat make it less cushy. We invite you to give the work a read. Perhaps this could open the way for more works in plantar fat pad augmentation?

Saturday, November 7, 2009

UofA Surgery's Armstrong Named "Cure Award" Winner by American Diabetes Association

Tania and David Armstrong Arrive at the Awards Gala

TUCSON, AZ. David G. Armstrong, Professor of Surgery and Director of the Southern Arizona Limb Salvage Alliance at the University of Arizona College of Medicine was given the American Diabetes Association's "Cure" award at a black tie gala held this weekend for his group's work in Amputation Prevention. "This is a honor that I share with our SALSA team, our Department and with our University", noted Dr. Armstrong, a past board member of the American Diabetes Association. "We have found that putting people together really makes a difference. The secret sauce that makes up SALSA is teamwork." Armstrong, a podiatrist and researcher, has produced more than 270 peer reviewed manuscripts and helped to develop the key classifications and guidelines that serve to direct diabetic foot care around the world. His SALSA unit, co-directed by renowned vascular surgeon Dr. Joseph Mills, has served as a model for care regionally, nationally,and internationally.




Free Diabetic Foot Care...in Pakistan


120 patients receive free treatment at Diabetic Foot Clinic
Sunday, November 08, 2009
By Shahina Maqbool
Islamabad

Ever since its establishment in March 2009, 120 patients with diabetic foot disease have received free treatment at the Diabetic Foot Care Clinic of the Pakistan Institute of Medical Sciences (PIMS). However, due to limited resources, patients do, at times, have to bear the cost of some drugs, specific tests not available at PIMS, and specialised foot wear necessary to prevent further damage to the affected foot.

According to consultant medical specialist and diabetologist Prof. Dr. Jamal Zafar, under whose supervision the clinic was established, the hospital has complete data of 101 patients; 29 patients lost to follow-up and the remaining 72 patients continued the follow-up till their treatment was completed.

Out of these 72 patients, 40 recovered completely and 29 recovered with disability i.e., they had minor or major amputations. Three patients died because of overwhelming sepsis developed due to delay in treatment; usually patients initially go to local quacks and general practitioners for treatment.

The cumulative rate of major and minor amputations at the PIMS Diabetic Foot Care Clinic stands at 40.27 per cent. These data suggest a tremendous success in treatment of such patients as the rate of amputation varies between 70-80 per cent in the absence of specialised diabetic foot care treatment facilities. Apart from this, the clinic also offers counselling for patients regarding foot care, diet plans, exercises and literature.

Minor debridements and dressing of wounds is done in the clinic, but if the wound is more complicated, then the patient is surgically managed by the Department of General Surgery under supervision of Prof. Dr. Tanvir Khaliq.

A certified dresser is also available at the clinic to provide specialised dressing facilities to patients at their homes so that they don’t have to visit the clinic on a daily basis for dressing, which is usually required for months. “This facility can be made available to patients in Islamabad and Rawalpindi at a very nominal cost if some NGO or philanthropist gets involved in bearing the cost,” Dr. Jamal pointed out.

The Diabetic Foot Care Clinic is working six days a week from 8 a.m. to 2:00 p.m. daily and registration is open for all diabetic patients, not only for treatment of patients having established diabetic foot disease, but also for counselling of diabetics regarding foot care, dietary and lifestyle modifications. A diabetes educationist is also available at the clinic every Monday and Thursday.

The PIMS Diabetic Foot Care Clinic is increasingly being recognised as a unique initiative of its kind in the whole region of Northern Punjab, NWFP, Kashmir and Northern Areas. The clinic follows a multidisciplinary approach for provision of care to diabetic patients in terms of prevention and treatment of a very common and disabling complication of diabetes i.e., diabetic foot disease, which is the commonest medical cause of amputation of extremities worldwide. “The idea behind the establishment of the clinic was not only to create awareness amongst diabetic patients regarding foot care, but also to provide specialised services to them under a single roof in terms of diabetic physician, surgeon and podiatrist,” says Dr. Sohaib Ejaz; resident in General Medicine, who has been specially trained and has got certification in diabetic foot care management. He added that all residents in the unit have been trained by seniors and are actively participating in diabetic foot care.

Order up a SALSAchino: Wound Care to Order?

We have been discussing "wound chemotherapy" for some time at SALSA. That is: delivery of specific agents (antimicrobials, anti-inflammatories, pro-angiogenic factors, anti-biofilm agents, growth factors). In fact, it is now a daily treatment regime on our service through modified negative pressure wound therapy modalities.

As we do this more frequently, we liken ourselves to the barrista at the local coffee joint or a bartender or a "mixologist". Dr. Joe Mills just called me during ward rounds and, after criticizing my work ethic for not joining him (he is very needy, mind you), he delivered some SALSAism gems. Some new terms of art related to our SALSA mixology:

SALSAlatte (like salicylate, an antiinflammatory)
Podobarrista
Plantar Flappochino

Feel free to email us with your ideas and experiences as you embark on your own good works.

Thursday, November 5, 2009

Armstrong/SALSA Tout Team Approach to Amputation Prevention at 35th Mexican Association for General Surgery International Symposium

Armstrong lecturing to Mexican Association for General Surgery's Symposium in Acapulco, Mexico from University of Arizona

David G. Armstrong, DPM, PhD, Professor of Surgery at the University of Arizona became the first podiatric surgeon to address the Mexican Association for General Surgery's International Symposium. The lecture, which was given by way of the University's biomedical communications unit to the congress in Acapulco, detailed the structure and function of the renowned Southern Arizona Limb Salvage Alliance (SALSA) and techniques to prevent amputation in people with diabetes. "We believe strongly that team trumps technology", noted Dr. Armstrong, "However, when both are combined, it is a really wonderful combination." The session, which was chaired by Surgeon Fermin Martinez de Jesus, President and Founder of the Mexican Diabetic Foot Society. This symposium was preceded by a pre-conference which included podiatric surgeon Stephanie Wu, Associate Professor of Surgery at Rosalind Franklin University of Medicine and Science as well as a "virtual" visit by Professor Armstrong.


Tuesday, November 3, 2009

From the APMA: Nearly 40% of African Americans Delay Preventative Diabetic Foot Care Because of Lack of Coverage

BETHESDA, MD -- 11/03/09 -- New national survey results show that nearly 40 percent of African-Americans with diabetes delay a visit to a podiatrist -- a critical member of a diabetes management team -- because they cannot afford the necessary medical care, according to the American Podiatric Medical Association (APMA).

The nationally balanced sample, which included 400 African-American men and women with and without diabetes, found that 38 percent of respondents with diabetes put off a visit to a podiatrist because they could not afford care, had no insurance, or care was not covered by their insurance plan. Additionally, while nearly all respondents (98%) agreed that proper foot care is vital, almost half (48%) admitted that they have never been to a podiatrist for a diabetic foot examination or treatment. African-Americans are twice as likely as Caucasian-Americans to develop diabetes.

"More than half of all African-Americans -- 54 percent -- reported in our survey that they have at least one family member with diabetes," said APMA President Ronald D. Jensen, DPM. "Diabetes has a tendency to be genetic, and the disease truly is a family affair. It is vital that our nation's health care reform plan include stipulations that ensure all Americans, both those with and at risk for diabetes, can afford the necessary diabetes care and management that they require."

Studies have shown that greater public awareness of diabetic foot care could positively impact the American health care system. According to an article in the Journal of the American Podiatric Medical Association, comprehensive amputation prevention programs have reduced amputation rates up to 70 percent -- saving the health care system up to $8 billion each year.

APMA's "Diabetes is a Family Affair" campaign -- which takes place during November's Diabetes Awareness Month -- encourages those with diabetes, as well as those at risk, to openly discuss the disease with family members. Diabetes, an American health epidemic, is often passed down from parents to children. While the survey found that 77 percent of African-Americans say they are willing to talk to their family about diabetes, those who do not have the disease are far less likely to do so than those who are currently suffering from it (59% vs. 95%).

Other results from the survey found that 47 percent of African-Americans with diabetes have experienced foot issues related to the disease, -- which can lead to a foot or leg amputation without treatment. For the results from the survey in their entirety, or more information about APMA's "Diabetes is a Family Affair" campaign, visit www.apma.org/diabetes.

Founded in 1912, the American Podiatric Medical Association (APMA) is the nation's leading and recognized professional organization for doctors of podiatric medicine (DPMs). DPMs are podiatric physicians and surgeons, also known as podiatrists, qualified by their education, training and experience to diagnose and treat conditions affecting the foot, ankle and structures of the leg. The medical education and training of a DPM includes four years of undergraduate education, four years of graduate education at an accredited podiatric medical college and two or three years of hospital residency training. APMA has 53 state component locations across the United States and its territories, with a membership of close to 12,000 podiatrists. All practicing APMA members are licensed by the state in which they practice podiatric medicine. For more information, visit www.apma.org.

Sunday, November 1, 2009

Mills, Armstrong Bring Toe and Flow to Indian Health Service Symposium

Photo (from L)
Joseph L. Mills, MD, Professor of Surgery, University of Arizona
David G. Armstrong, DPM, PhD, Professor of Surgery, University of Arizona


The renowned Southern Arizona Limb Salvage Alliance (SALSA) service of
the Department of Surgery at the University of Arizona had their
teamwork on full display this weekend in a novel simultaneous lecture
at the Native American Cardiology Program/IHS Conference, held in
Scottsdale, Arizona. "This was a truly fun program.", noted Professor
Armstrong. "To be able to take the dynamic, debate, and camaraderie we
have in the clinic, on the wards and in the operating room to the
podium is a rare treat." Professors Armstrong and Mills described the
now well-known "Toe and Flow" concept for amputation prevention.
Armstrong went on to suggest "It is a sad fact that amputations are
several times higher amongst Native Americans in the USA than for
other Americans. The fact that it is a fact, though, doesn't make it
right or necessary. These problems are preventable. That's why we come
together in symposia like this." The program, chaired by noted
cardiologist Beth Malasky, included clinicians, scientists and
epidemiologists from throughout the nation.


Saturday, October 24, 2009

SALSA adds "Sole" to Renowned Bioimaging Institute Program



David G. Armstrong, Professor of Surgery and Director of the Southern Arizona Limb Salvage Alliance (SALSA) joined six other renowned researchers to present at this year's Advanced Research Institute for Biomedical Imaging (ARIBI) workshop. "We have learned long ago that no clinician is an island when caring for a disease", noted Armstrong, "The same can be said for scientists. When people doing cutting edge optics and signal processing combine with clinicians asking basic questions, the result can be transformative." Armstrong presented a wide range of imaging technologies being developed and tested by SALSA, including 3-D imaging tools to, as Armstrong put it, "Tivo, or time-shift the physical exam" for later playback and analysis to new methods of measuring skin temperature by patients at home that have been shown to reduce risk for limb threatening diabetic foot ulcers. The program, coordinated by ARIBI's Director, Professor Ron Lynch, included topics ranging from cutting edge imaging of the nervous system to novel methods to monitor cardiac and oncologic therapies.





Monday, October 19, 2009

University of Arizona's SALSA Spices up the Palais Des Congres de Montreal for IDF World Diabetes Congress




The Southern Arizona Limb Salvage Alliance (SALSA) of the Department of Surgery at the University of Arizona College of Medicine was well represented at the largest diabetes symposium in the world today in Montreal. SALSA Scientist Dr. Manish Bharara is presenting three SALSA studies on Thermometry (used to predict wounds), the team approach to amputation prevention (commonly referred to as the "Toe & Flow"-- a term coined by SALSA) and Diabetes Related Amputations. These works were co-authored by SALSA clinician-scientists Prof. David G Armstrong, Prof. Joseph Mills, Prof. Horacio L Rilo and Dr. Ryan Fitzgerald. "I am enormously pleased with how well these have been received", noted Dr. Bharara. "It is an indication of the global epidemic we're in and the high quality work going on at centers, worldwide to stem the tide of amputations."


Photo caption:

SALSA's Manish Bharara, PhD and Professor Hermelinda Pedrosa, MD, of Brasilia during IDF Poster Session

Press Release: Latest diabetes figures paint grim global picture


International Diabetes Federation says epidemic out of control

The International Diabetes Federation (IDF) released new data today showing that a staggering 285 million people worldwide have diabetes. The latest figures from the IDF Diabetes Atlas indicate that people in low and middle-income countries (LMCs) are bearing the brunt of the epidemic, and that the disease is affecting far more people of working age than previously believed.

Read the full press release

"Aggressive Care Saved my Foot"

Message from the BBC:

by Jane Elliott
Health reporter, BBC News

John Parker
John Parker's foot was saved

This article contains a graphic image of an infected limb.

Pensioner John Parker, from Bromley, Kent, walks with a stick to help him balance.

But despite this John, who has type 2 diabetes, knows he is a lucky man.

For he has had months of diabetic ulcers and could have lost a few toes, or even his foot.

Thankfully, through aggressive treatment, doctors were able to save all John's toes.

But recent figures show that many are not as lucky.

The NHS spends £600m a year on treating foot problems in people with diabetes, and £252m of this is spent on amputation.

Diabetes can cause damage both to the nerves of the foot, and to the blood supply that keeps the foot tissues healthy.

I think I must have very good healing properties - my mother lived to 104
John Parker

Both can lead to foot ulcers and slow-healing wounds which, if they become infected, can result in amputation.

Professor Mike Edmonds, a diabetic consultant at King's College Hospital, London, treated John.

He said there are about 100 amputations a week in the UK because of foot ulcers.

But he believes at least half of these could have been prevented.

The key, he says, is to ensure patients get speedy, aggressive treatment, provided by experts across a range of disciplines.

It is an approach that Professor Edmonds has pioneered at his clinic, which takes on patients with the most severe of symptoms.

It has the facilities to offer interventions such as radiology to improve circulation in the legs, and bypass surgery to clear blockages in damaged blood vessels.

"Our remit is to get patients out of trouble quickly," said Professor Edmonds.

"It is all about preventing the natural disease progressing to an irretrievable state.

"It is about putting all these measures into use to preserve the limb."

Saving limbs

The clinic sees around 20-35 cases each day in the foot clinic, but only have about two to three amputations each year.

It compares very favourably with other units - particularly as some patients have been referred for a second, or even third, opinion.

John - who has had heart and renal problems - was admitted to the clinic as an emergency.

He realised he could lose some toes - but was not aware until after his treatment that his whole foot was at risk.

He underwent bypass surgery to clear the blockage in his leg and angioplasty to widen his femoral artery.

Diabetic foot. Pic caption: Eamonn McNulty/Science Photo Library
Diabetics can cause severe damage to foot tissues

"Possibly he would not have been considered for surgery in other places because of his heart problems," said Professor Edmonds.

"But here he had a package of multi-disciplinary care that saved his leg."

John's wife Sheila agreed that her husband had been a lucky man.

"They were a bit hesitant because of his heart trouble," she said.

"They very carefully explained all the pros and cons.

"They told us afterwards that he could have lost his foot - but it didn't sink in at the time."

John agrees that the hospital was vital in his recovery, but also credits his own genes for helping.

"The bypass has healed perfectly," he said.

"I think I must have very good healing properties - my mother lived to 104."

Thursday, October 15, 2009

The 2010 SALSA Fellowship at University of Arizona is open for applications

Deadline for Applications: 1 January, 2010

The fellowship’s central aim is to train and develop future leaders in this field.

The Southern Arizona Limb Salvage Alliance (SALSA) in the Department of Surgery, University of Arizona, is currently seeking qualified applicants for the position of Diabetic Foot Fellow for the July 2010-2011 academic year. Foci of fellowships, depending on the applicant, range from basic research to clinical research to robust reconstructive foot and ankle surgical training in limb salvage techniques in a uniquely integrated "toe and flow" service model. Most candidates combine a hybrid of clinical and research foci.

Ideal candidates should possess an already strong academic background with a keen interest in academic development, inpatient and outpatient care, and research. While preference is given to podiatrists, we train fellows from a variety of medical, surgical, and research backgrounds.

This fellowship was developed to meet the unique and varied health, education and research needs of the field of diabetic foot care. SALSA and University Medical Center provides care for patients throughout the Southwest, with regular out of state and international consultations. SALSA is one of the most dynamic and productive clinical/research teams in the world dedicated to the diabetic foot, wound healing, and limb salvage.

Graduates of Armstrong-led fellowship programs include many of the leading clinicians and researchers in the field, worldwide.

Applicants should forward a letter of intent (preferably via email) with their curriculum vitae to the attention of:

David G. Armstrong, DPM, PhD

Professor of Surgery
Director, SALSA
Department of Surgery
University of Arizona College of Medicine
1501 North Campbell Avenue
PO Box 245072
Tucson, Arizona, 85724-5072
dga@email.arizona.edu

Wednesday, October 14, 2009

SALSAisms: THE LIST

On our SALSA toe and flow service, we often operate in close quarters. This
has led to many appellations for and colloquialisms used by various team members. Here is a
partial (and running) list:
  1. Vaya con Dedos: A parting wish upon leaving the SALSA clinics or operating room. "Go with Toes" (rather than without)
  2. Carpe Dedos: Sieze the Toe (while this may have come up before, Tim wanted to ensure it made the list).
  3. Hammertosis Fugax: A person with diabetes and blindness who develops a neuropathic wound on a contracted toe. This is not to be mistaken with Amaurosis Fugax, which is blindness due to transient retinal ischemia. The two may coexist, forming a dual fugue kind of scenario
  4. Missle Toe: a penetrating traumatic toe injury in a person with diabetes
  5. Turf Toe: a referral to SALSA without a solid medical rationale
  6. ManifesTOE: An operative report following an amputation prevention procedure (bypass or incision and drainage or graft/flap.
  7. Toemigo/Flowmigo (self explanatory)
  8. FreeToes with SALSA (mantra for limb salvage)
  9. Toebama and Joe the Plumber (nicknames designed to politicize the Toe and Flow team-- however, there are no wedge issues in SALSA-- just wedge pressures).
  10. Toe and Flowmance (bromance between podiatrist and vascular surgeon)
  11. The Toebel "piece" prize: Award for prevention periodically given for keeping a person intact.
  12. FloJoe (Armstrong's affectionate nickname for Mills)
  13. Toe Bless Oblige (the obligation to improve foot care)
  14. Podshine
  15. Der DopplerGanger - referring to one's vascular partner
  16. Sir I-Pod (international podiatrist)
  17. PodCaster
  18. Toe Mechanic
  19. SALSA Bowl (for our laboratories)
  20. Podiatric physician extender (given to our vascular surgical team)
  21. SALSA Relay: handing off a particularly challenging patient between SALSA team members.
  22. Non-life partner: one's professional SALSA partner
  23. Marooned on the Pedal Peninsula: trying to heal a wound on the foot without sufficient blood flow.
  24. Impaired Toemerular Filtration Rate (TFR): End Stage Renal Disease's ravages on healing.
  25. MalaPodism: diagnosing a foot problem incorrectly-- or as something else.
  26. EuTOEpia: A state of podiatric and vascular bliss.
  27. Podtification: contemplation on a particularly difficult patient.
  28. Podogenic: A particularly impressive foot photograph
  29. Podigraphy: Medical imaging for the feet
  30. The Sole Train: A typically busy Armstrong-Mills tuesday SALSA clinic
  31. Sole searching: a particularly thorough foot examination
  32. Filet of Sole: the proper way to drain an extensive plantar space infection
  33. Plantar fascist: one who lines him or herself against a team approach to limb salvage.
  34. Toereador: one who fights diabetic foot infections
  35. Sourtoe roll: Patients with infections that tend to roll in on Friday afternoon.
  36. Toeligarchy (Flowligarchy)/singular: Toeligarch: The "Toe and Flow" team, run by benign digital despots.
  37. Podiatrust: faith in ones SALSA parter (from George Andros)

There are many more. We will try to update this list periodically. Any suggestions? Send a note to: armstrong@usa.net

Tuesday, October 13, 2009

The Wound Healing Spectrum: A Timeline for Utilization of Advanced Therapies

There has been a consistent request for some clarity on where various classes of wound healing modalities may fit along a timeline. Rather than adhere to a "one size fits all" concept, more clinicians have moved toward a multimodal approach. This manuscript, which was published today in the maiden voyage issue of the Journal of Diabetic Foot Complications (an open access journal) continues this discussion.

The Wound Healing Spectrum

Tuesday, October 6, 2009

APMA News Features Toe and Flow

The latest APMA News features a cover story on the APMA-SVS Toe and Flow Collaborative from its inception in Tucson with SALSA to plans for the future.

The article along with a related article on an up and coming LA-based Toe and Flow Unit under the aegis of Drs. George Andros, Lee Rogers and Nick Bevilacqua, is included here. Enjoy.


Apma News Oct 2009

Friday, October 2, 2009

Interview with Dr. Armstrong: "Meet the Masters"


For those of you who wanted a link to the recent "meet the masters" session, hosted by Dr. Bret Ribotsky, feel free to listen to it here.


Monday, September 28, 2009

Meet the Masters Series Enters the SALSA Bowl: Tuesday at 9PM Eastern/6 Pacific (http://bit.ly/1at8wN)

I'm honored to have been invited by the always compelling Dr. Bret Ribotsky to join him for a "Meet the Masters" interview Tuesday, 28 September at 9PM Eastern, 6PM Pacific. Go to www.PodiatricSuccess.com
For more information and join in!


Saturday, September 26, 2009

SVS And APMA Alliance Provides Better Care To Diabetic Patients

The Society for Vascular Surgery® (SVS) and the American Podiatric Medical Association (APMA) announce formation of a strategic collaboration to help advance the care of patients with critical limb ischemia, especially in the diabetic population. The multidisciplinary team approach was outlined during a meeting between leaders of both associations in August.

The collaboration includes an agreement approved by the respective boards of SVS and APMA to identify clinical issues, questions important to both memberships, and to work together to find solutions that will benefit our patients. Specifically, in the August leadership meeting, it was agreed to:

1. Appoint a group representing both organizations to write a joint statement on the multidisciplinary team approach to the care of diabetic foot

2. Produce a supplement on the care of the diabetic foot that will be jointly published in the Journal of Vascular Surgery® and the Journal of the American Podiatric Medical Association

3. Establish joint postgraduate courses to be held at the annual scientific meetings of both organizations

4. Collaborate on practice guidelines and reporting standards dealing with the care of diabetic foot

5. Collaborate on advocacy and public awareness efforts in areas of common interest

"Vascular surgeons and podiatrists have always worked together to provide the best care for patients with diabetic foot problems," said Anton N. Sidawy, president, SVS. "We are pleased to formalize an alliance with APMA so that we can jointly work on the prevention and management of diabetic foot, which would positively impact the care of our patients. Our staffs will conduct public education programs to raise awareness and promote prevention."

A Management of the Diabetic Foot session was a highlight at the SVS' 2009 Vascular Annual Meeting®.

Friday, September 25, 2009

Toe and Flow: History in DC

Front (L-R): Anton Sidawy (President, SVS), Ron Jensen (President, APMA)
Back: Richard Neville (Georgetown), John Steinberg (Georgetown), David G. Armstrong (University of Arizona/SALSA), George Andros (Los Angeles), Christopher Attinger (Georgetown)

In the annals of amputation prevention, this will be remembered as a great day. The American Podiatric Medical Association (APMA) and the Society for Vascular Surgery (SVS) today ratified a historic collaboration that will continue efforts begun by many teams to enhance work toward amputation prevention.


Diabetes Foot Specialists Say Cost-Effective Wound Therapy Underused Due to Healthcare Reimbursement Incentives


WHAT: Every 30 seconds, across the globe an individual loses a limb due to poor diabetes management. In the U.S., diabetes affects nearly 24 million people. When poorly controlled, diabetes results in nerve damage and poor circulation to the legs and feet. When this occurs, patients lose the ability to sense foot pain injury, and, when left untreated, which leads to foot ulcers, reduced mobility and amputation. *Approximately 85% of amputations are preceded by a foot ulcer that doesn’t heal.

Preventive care makes the difference. Leading podiatric experts, Dr. John S. Steinberg of Georgetown University Hospital’s Department of Surgery, and Dr. David G. Armstrong, director of the Southern Arizona Limb Salvage Alliance (SALSA), are pioneers of the "toe and flow’’ approach, which they say is more effective than repeated endovascular stent procedures. They urge a team approach to diabetic foot care and argue that current health reimbursement incentives work against delivery of evidence-based guidelines and cost-effective care.

WHEN:

September 24-26 Georgetown Diabetic Limb Salvage Conference

WHERE:

JW Marriott Pennsylvania Avenue Hotel
Washington, DC

WHO:

David G. Armstrong, DPM, PhD, Professor of Surgery and Director of the Southern Arizona Limb Salvage Alliance (SALSA), Arizona Health Sciences Center, Tucson, AZ.

www.diabeticfootonline.com

John S. Steinberg, DPM, FACFAS, Department of Surgery and Co-Director of the Wound Healing Center, Georgetown University Hospital, Washington, D.C.

Wednesday, September 23, 2009

From PNAS: Using Math to Heal Wounds

By Laura Sanders, Science News

A mathematical model may help clinicians speed the healing of persistent bedsores, diabetic ulcers and other types of chronic wounds, scientists report online September 21 in the Proceedings of the National Academy of Sciences.


Chronic wounds are a serious public health problem, affecting 6.5 million people in the United States, says study coauthor Avner Friedman of Ohio State University in Columbus. These wounds linger, often because they don’t get enough blood flushing them with oxygen and other healing factors. Friedman and his colleagues’ new model is the first to predict the healing behavior of such blood-deprived — or ischemic — wounds, he says.

Mathematician John Dallon of Brigham Young University in Provo, Utah, says that the new model is the “start of something that could give valuable insight to the wound healing problem in the future.”

Friedman and his colleagues started by modeling a simple, flat wound at the skin’s surface. First the team developed equations to represent the springy, elastic tissue near the wound. Another set of equations predicted when and how healing factors enter the wound. Such factors include pathogen-busting white blood cells, capillary sprouts, blood-vessel–forming proteins and oxygen concentrations. By tweaking the amount of oxygen near the wound, researchers could model the healing of nonischemic and ischemic wounds.

The model’s simulations agreed with wound healing times found in experiments, the authors say. An eight-millimeter–wide wound under normal conditions is predicted to completely heal in about 13 days. But an ischemic wound would be only 25 percent healed after 20 days. The model also predicts that under low-oxygen conditions, fewer white blood cells can reach the wound.

The new model may help clinicians pinpoint better ways to treat wounds, Friedman says, for example by providing guidance about when oxygen and pressure therapies will be most effective.

Although the model includes many variables, others remain unexplored. “Of course, wound healing is extremely complex, and even in their model they have, out of necessity, ignored many things,” Dallon says.

Friedman and his colleagues would like to include in the model the behavior of genes, microRNAs and proteins known to speed along healing. The team would also like to model the tissue underneath the surface of the wound. These kinds of complexities are needed “to really make a big dent into this serious problem,” Friedman says. “Of course, we won’t cure wound healing with mathematics, but we can suggest ideas to biologists.”

Tuesday, September 22, 2009

Against "Proceduralism"-- Can Team Trump Technology in the Evolving Healthcare Discussion?

Can teams trump technology in the new healthcare debate? I ask because I find myself frustrated by patient after patient we see in our SALSA unit, referred from elsewhere, who have been relegated to amputation. This is not because they haven't had access to technology. In fact, most have had extensive work done. What frustrates me, and I know my SALSA partners, as well, is the lack to access to team.

I am, as we speak, sitting in front of an x-ray of a patient who had extensive endovascular intervention-- but no follow-through to manage her complex wound when the isolated procedure failed. Why? The cynic would suggest that it is because the procedure was reimbursed well, but the necessary healing and preventative followup was perhaps less fiscally rewarding. Therefore, one may posit it easier to justify doing nothing or cutting the limb off.

The point is that our current healthcare discussion must work out some sort of balance to support medical and surgical teamwork instead of simply one-off fee for service proceduralism. I know there must be a way. Too many smart people are involved and committed for this opportunity to pass.

Monday, September 21, 2009

Common Foot Problems and Their Solutions

This was posted today on the outstanding patient website "Diabetes Self-Management"


by David G. Armstrong, DPM, PhD
People with diabetes are often told to pay close attention to their feet — and for good reason. While having diabetes doesn’t make it more likely that you’ll injure your feet in the first place, having certain common diabetes complications raises the risk of minor foot problems becoming major foot problems if not treated promptly.

One of those complications is peripheral neuropathy, or damage to the nerves in the feet and lower legs. Peripheral neuropathy can cause a loss of sensation in the feet, meaning that heat, cold, and/or pain may not be felt. As a result, a person becomes more vulnerable to getting burned if he steps into hot water or walks barefoot on hot pavement or sand, and he’s also more likely to let small blisters, cuts, and scrapes on his feet go untreated since he doesn’t feel them.

The other common diabetes-related complication that raises the risk of foot problems is reduced blood circulation to the feet. Blood carries oxygen and other nutrients and substances that are necessary for wound healing. When blood circulation is reduced, wounds heal more slowly and have more time to become infected.

The good news is that many if not most major foot problems are avoidable. How to do it? Maintain the best blood glucose and blood pressure control possible. Wear well-fitting shoes or slippers at all times (except for sleeping or bathing), and check inside them for foreign objects before putting them on. Check the tops and bottoms of your feet and between your toes every day, especially if you know or suspect you have either neuropathy or reduced blood circulation. Look or feel for any signs of rubbing, injury, or infection, such as redness, broken skin, or areas of unusual warmth.

If you develop a foot problem, attend to it immediately. Apply first-aid measures to small cuts or blisters, then check daily to see whether the wound is healing. Stop wearing any shoes or socks that rub on or bother your feet in any way. And call your diabetes care provider promptly if small wounds do not heal quickly or if you sustain a serious foot injury.

Resolving common problems
Having any kind of foot problem can interfere with your daily life. Here’s how to address some common complaints and keep your feet in good health.

I’d like to walk more for exercise, but my feet hurt when I walk.

Your feet may be hurting for a number of reasons, most of which can be prevented or treated by changing your activity, your shoes, or the insoles in your shoes.

In general, the more active you are, the better you will feel, and walking is a good choice of activity for many people. However, if you have diabetes-related foot problems, check with your doctor about how much walking is safe for you. It may be advisable to alternate between walking and activities that put less stress on your feet, such as bicycling, swimming, or water aerobics. (Be sure to wear water shoes when exercising in water.)

If walking is safe for you, choose walking shoes that are flexible enough to walk in easily but that also provide support and cushioning. Wear socks that provide some cushioning and that wick away sweat. Remember that even the best shoes won’t last forever, and the more you weigh, the faster your shoes will wear out. Generally, shoes will last for no more than 500 miles, which usually equals three to six months of regular walking. Plan on buying a new pair of walking shoes before the old ones wear out so that you can “break in” the new ones a little at a time. (Although shoes should fit well and be comfortable at the time of purchase, it’s recommended that you wear them for only short periods at first and gradually lengthen the time you walk in them.)

If your feet still hurt with well-fitting shoes, or your feet have changed shape so much that no pair of shoes fits well, a podiatrist or other foot expert may be able to recommend insoles or other shoe inserts to allow you to walk comfortably. However, you will still need to replace your shoes at 500-mile intervals (or earlier), and you will most likely need to replace your inserts as well.

I put moisturizing lotion on my feet every day, but the skin on them is still dry and itchy.

Try switching to a thicker lotion or cream, and apply the product more than once a day. For very dry skin, moisturizer should be applied two to four times a day. However, be careful not to put too much between your toes. Too much wetness in this area increases the risk of skin breakdown and infection.

If increased moisturizing doesn’t improve dryness, flaking, or itching, see your primary-care doctor or foot doctor. Very itchy skin is sometimes a sign of a fungal infection such as athlete’s foot.

I have thick calluses on the bottoms of my feet. How can I get rid of them?

Calluses are your body’s way of telling you that you are applying too much pressure to a given area. If you do not have neuropathy, you can use over-the-counter tools to “grate” or file down the callus. The Ped Egg, for example, works well. After reducing the callus, moisturize the skin with a high-quality cream.

If you have neuropathy, calluses are far more serious, because you run the risk of developing an undetected wound underneath the callus. Do not try to treat calluses yourself; instead, have your foot doctor check them regularly. You can prevent calluses in the future by modifying the shoes or insoles you wear to reduce the stress on the area getting callused. Over-the-counter insoles can sometimes work well. For more significant problems, your foot specialist may prescribe insoles or shoe modifications.

Rarely, surgery is required to correct the underlying deformity leading to calluses. This may be considered as an option if a callus puts a person at high risk for developing a foot ulcer.

I’d really like to get a pedicure so my feet look good in sandals, but I’ve heard that people with diabetes shouldn’t get pedicures. Why is this?

People with diabetes are often advised not to get pedicures because of the possibility that salon workers will create small (or large) breaks in the skin while performing the pedicure. Any break in the skin is an access point for dirt and germs, possibly leading to an infection. The other concern about pedicures is that the toenail clippers and other implements used will not be clean, also raising the risk of acquiring an infection at the nail salon.

This doesn’t mean that pedicures are completely off-limits for people with diabetes who have good foot health. Provided the salon is reputable and has a good record of safety, you can get pedicures. However, if you have neuropathy or significant vascular disease, it’s best to forego pedicures: The potential consequences of getting an infection are too high.

I have a hard time cutting my own toenails. Is this something my doctor or a nurse could do for me?

Yes. It is best if a trained medical professional does this, particularly if you have neuropathy or vascular disease. Neuropathy can cause you not to notice small cuts that may occur if toenails are cut improperly or too short, and vascular disease in the legs and feet make you more vulnerable to infection of wounds on the feet.

Your health insurance may cover this type of foot care, but only if your doctor or podiatrist provides evidence that it is medically necessary.

My doctor says I need to treat the fungal infection in my toenails, but I don’t want to take another drug. How important is it really to treat this?

Generally, nail fungus is a cosmetic problem. However, when you have diabetes, fungal infections of the toenails can put you at greater risk for other types of infections and skin problems, particularly as you age. These include bacterial and secondary fungal infections of the skin. For this reason, if your doctor recommends it, you may benefit from a local or systemic treatment for nail fungus.

I have seen advertisements for laser treatment of fungal nails. Is that a good idea?

While it may stand to reason that laser therapy might be effective at killing fungus, the products and treatments currently being advertised really have no data behind them to back them up. If you have otherwise healthy feet and money to spare, you may want to give it a try. However, if you have neuropathy in your feet, vascular disease, or other skin conditions on your feet, I would suggest speaking to your doctor about how best to treat a fungal nail infection.

My feet have changed shape over the years, and it’s hard to find shoes that fit.

It is normal for your feet to flatten very slightly and to change shape, becoming longer and wider, as you age. It’s possible for your shoe size to increase by one or even two sizes over time. That being the case, it is very important to have your feet measured each year to assess your shoe size. A study conducted some years ago by our team in Arizona suggests that three-quarters of people with diabetes wear shoes that are at least one size too big or too small. (Shoes that are too big may allow the feet to slide around, possibly leading to blisters.)

I recommend, at the minimum, an annual visit to your foot specialist for an evaluation. If you have or develop risk factors for diabetes-related foot problems, your specialist may recommend prescription shoes or specific types of over-the-counter shoes. It may also be worth seeking out the services of a certified pedorthist if you have hard-to-fit feet. These footwear specialists may work in medical offices that provide foot care or are sometimes on staff at retail shoe stores that specialize in comfortable shoes. The Pedorthic Footwear Association Web site (www.pedorthics.org) has a search function to find credentialed pedorthists by location.

Shop for shoes later in the day, because feet can swell — sometimes imperceptibly — throughout the day. A shoe that fits well in the morning may be too tight by late afternoon. Buy shoes that provide arch support where you need it and enough room in the toe box for your toes to wiggle a little. Your heel should not lift more than half an inch when you walk.

It’s important that socks fit, too. Look for seamless socks or socks with seams that do not run across the bottoms of the feet or along any bony parts where they can cause pressure. White or light-colored socks are recommended, because any bleeding from a wound on the foot will be noticed quickly.

My feet smell terrible when I take off my shoes. What can I do about this?

This is a very common problem that is generally caused by the growth of bacteria on your feet. Alternating between pairs of shoes so that each pair gets a chance to dry out completely, and changing your socks more than once daily may help. Sprinkling the insides of your shoes with ordinary talcum powder may also reduce odor. If these steps are ineffective, speak to your doctor about alternative approaches. Do not try any home remedies without speaking first to your doctor.

Other common concerns
Unfortunately, many people with diabetes eventually develop neuropathy in their feet, so it’s important to have your doctor examine your feet at least once a year and to know how to protect your feet if you develop it.

My feet are sometimes numb when I wake up in the morning. Does this mean I have diabetic neuropathy?

You may, and your diabetes care doctor or foot specialist can evaluate this with a few simple tests in his office. It’s important to know whether you have neuropathy, or “loss of protective sensation,” in your feet, because that allows you to be proactive about protecting your feet.

Why do doctors say I should check my feet every day?

A daily foot check is one of the best ways to prevent foot complications, including ulcers. It is especially important if you have neuropathy, since you may not feel small injuries to your feet, but it’s a good habit for anyone to check their feet daily for signs of shoe rubbing, blisters, cuts, and calluses. These signs can alert you to the need to change your shoes or socks or to apply first aid. Once you’ve attended to a minor foot problem, check it daily to see if it’s healing normally.

What if you can’t see the bottoms of your feet? Ask a member of your household to look for you, or use a mirror to look yourself. A product called the Insight Foot Care Scale is both a scale (to weigh yourself) and an illuminated, magnified mirror. It automatically lights up after you weigh yourself as a reminder to check your feet. (You should sit down before examining each foot in the mirrored surface.) You can also press a button to turn on the lighted mirror if you don’t wish to weigh yourself first. (Learn more about Insight products at www.focusonyourfeet.com.)

If you have vision loss and cannot see your feet even in a magnified mirror, feel them carefully with your hands. Rub the back of your hand (which is especially sensitive to temperature) along each foot to help you detect cool spots, which may indicate impaired circulation, or unusually warm areas, which could be signs of inflammation and infection.

I’ve had an ulcer on my foot, and I’d really like to prevent another one. How can I do this?

In addition to performing a daily visual or manual foot check, using a skin thermometer to detect areas of inflammation on the feet can be very helpful. The TempTouch is an example of such a thermometer. (Read more about using the TempTouch at www.temptouch.com.)

Inflammation is a sign that a wound may be developing. By measuring the skin temperature at specific points on both feet and comparing the corresponding points on each foot, inflammation can be caught early. A difference of more than 3–4 degrees indicates that a hot spot may need to be looked at by a doctor.

Reason for hope
Attending to minor foot problems early is the best way to prevent major ones. But if you develop a more serious problem, don’t give up hope. Each year, new products and methods are developed for treating diabetes-related foot problems. Take advantage of these medical advances by bringing your foot problems to your primary-care or foot doctor’s attention promptly. Then take an active role in following through with your foot professional’s recommendations. When you work together with your medical team, there’s good reason to hope that your feet will last a lifetime.



Dr. Armstrong is Professor of Surgery and Director of the Southern Arizona Limb Salvage Alliance (SALSA) at the University of Arizona College of Medicine in Tucson, Arizona. You can follow Dr. Armstrong's blog posts and other writings via Twitter at www.twitter.com/dgarmstrong or go directly to the SALSA Web site, www.diabeticfootonline.com.

Tuesday, September 15, 2009

Editorial on PBS: SALSA, Limb Salvage and Diabetes

The following editorial aired this evening on PBS's Arizona Illustrated. The original link is here. video

Monday, September 14, 2009

SVS/APMA Toe and Flow Collaborative Lectures Made Freely Available for View/Download

The historic combined "Toe and Flow" Symposium borne out of collaboration between the Society for Vascular Surgery and the American Podiatric Medical Association is now freely available for view or download. Feel free to click here to view.

Sunday, September 13, 2009

Health Reform Should Include Diabetes 'War'

Thanks to Dr. Lee Rogers for Picking this up:

Health Reform Should Include Diabetes 'War'

By Mort Kondracke
It would be entirely fitting for Congress to rekindle the "war on cancer" in response to the death of Sen. Edward Kennedy (D-Mass.), but another disease worthy of a war is diabetes.

Cancer kills more people each year - 560,000, according to the Centers for Disease Control and Prevention, compared with 233,600 for diabetes and its complications.

But the CDC estimates that the diabetes figures are hugely underreported and that the actual numbers may be 65 percent higher, or 386,000.

Kennedy's death from glioblastoma, an aggressive brain cancer, is one reason for a renewed attack on cancer.

But, as Gina Kolata pointed out in an illuminating article in the New York Times, Kennedy called for a cancer war months before President Richard Nixon declared it in his 1971 State of the Union message.

Kennedy advocated a larger research budget than Nixon's and enhanced status for the National Cancer Institute - ideas Nixon agreed to support as long as Kennedy's name was not on the bill.

Kennedy agreed and Nixon signed a cancer bill in December 1971. Cancer has received one of the largest budgets at the National Institutes of Health ever since, but clearly it is still not conquered.

The reason for a war on diabetes is that, like some cancers, Type 2 diabetes - the most prevalent type - is heavily a "lifestyle disease" resulting from overeating and lack of activity. Therefore, it's preventable.

(Type 1, or juvenile diabetes, occurs when the body's own immune system attacks the pancreatic cells that produce insulin, the hormone that processes glucose.)

Diabetes can result in ghastly consequences for its 24 million victims, including heart disease, stroke, blindness, kidney failure, amputations and nervous system disease, and it is hugely expensive to the economy.

The CDC estimated the national cost of diabetes in 2007 at $174 billion, including $116 billion in medical expenditures and $58 billion in lost productivity.

According to a 2007 study by the policy research firm Mathematica, the federal government spent nearly $80 billion of that, 12 percent of all federal health spending.

Yet, Mathematica found, 19 different federal agencies spent only $3.9 billion on disease prevention or health promotion activities with some impact on diabetes.

If a "war on diabetes" were declared, it ought to begin with a war on obesity, the epidemic most responsible for rising incidence of Type 2 diabetes among both adults and, increasingly, children.

In 1980, the CDC estimated that 47 percent of U.S. adults were overweight. In 2006, it was an astounding 66 percent, and 34 percent were obese - 72 million people.

Insurance companies and employers have developed incentives for workers to lose weight and become fit such as insurance premium reductions or paid-for gym memberships, but fighting obesity ought to be a major focus of health care reform.

David Snow, CEO of the pharmaceutical distributor Medco, recommends that the government run TV ads to promote healthy lifestyles akin to its fried-egg "your brain on drugs" ads or Smokey Bear anti-forest-fire spots.

I'd go further - pushing videos in school health classes showing diabetes amputees and kidney disease victims the way drivers' ed classes used to scare kids with car wreck films.

Conservatives will surely scream "nanny state" at such moves, but the fact is, obesity costs - as much as 27 percent of recent increases in national health spending, according to health analyst Kenneth Thorpe.

Beyond combating obesity, there's a need for better diabetes screening in government health programs. Medicaid and Medicare ought to adopt the kind of intensive disease-management techniques that many insurance plans employ.

Many plans hire contractors employing nurses to routinely check on patients' blood sugar levels and monitor complications - and pay doctors to prevent complications, not just treat them.

There's increasingly a role for technology. The computer chip maker Intel has deployed a series of home monitoring and communications devices, but is stymied by Food and Drug Administration regulations from going as far as it could.

In Asia, for instance, cell phones are equipped with glucose-testing kits that transmit data to a monitor. Here, the FDA would have to re-approve such a device every time its technology was updated.

How much of the government's $80 billion annual diabetes outlay - expected to triple by 2020 - could be saved by intensive prevention and management? It's a disputed point.

The Congressional Budget Office only estimates costs and savings within a 10-year "window," whereas chronic disease management probably would show results over a longer period.

A new study in the journal Health Affairs estimated that what amounts to a "war" on diabetes, costing $800 million a year, would merely pay for itself over 25 years, not cut the actual costs to the government.

But such a war surely would prevent many strokes, heart attacks, leg amputations and kidney failures. It's hard to believe that wouldn't save money, too.

checkTextResizerCookie('article_body');
Mort Kondracke is the Executive Editor of Roll Call, the newspaper of Capitol Hill since 1955. © 2007 Roll Call, Inc.

http://www.realclearpolitics.com/articles/2009/09/12/_health_reform_should_include_diabetes_war_98268.html at September 13, 2009 - 10:12:46 PM CDT

Friday, September 11, 2009

2009 British Medical Book Competition Awards

I just received word from my colleagues on the other side of the SALSA pond that  2 of the 3 shortlisted books for top awards at the BMA Ceremony this past were on the diabetic foot. As many of you know, this would have been unheard of even 10 years ago. Congratulations to Profs. Ben Lipsky, Lee Sanders, Mike Edmonds and Ali Foster!

Results of the competition announced at the Awards Ceremony 8 September:
First Prize
The Diabetic Foot: Essentials of Managing Infectious Complications
Benjamin A Lipsky - Current Medicine Group, August
2008 ISBN: 9781858734255

Highly commended
Practical Manual of Diabetic Foot Care.
2nd edition
Michael E Edmonds, Alethea VM Foster, and Lee
Sanders - Wiley-Blackwell, January 2008
ISBN: 9781405161473
 


Thursday, September 10, 2009

From Diabetes Mine: A Foot Scanner To Prevent Amputations

Congratulations to the folks at MeDavinci for this device. We have long been advocating a "personal health network". This home foot portal is a definite first step.

________________

The Vincent 50 for Diabetic Feet
Speaking of taking care of your diabetic feet, I was contacted this week by a European company called MeDaVinci working feverishly on a high-tech home scanning device that they hope will prevent amputations in thousands of patients who already have neuropathy.

Their system is called the Vincent 50 — after the St.Vincent Declaration, a decree signed by global health organizations in 1989 that vowed to cut the rate of diabetes-related foot amputations by 50%.







Yes, it’s a chunky box that looks like something dreamed up for The Jetsons, but it is 2010 state-of-the-art, the company tells me. Meant to be used daily by patients with existing foot damage, it automatically takes images of the soles and a “temperature profile of the foot.” This precise information is then immediately transmitted to a call center, where trained nurses “can make an overlay with earlier images and distract the pixels, to see if there are changes in inflammation or callus formation. If so, the patient is called and urged to visit the doctor or podiatrist.”

Company spokesman Ger Biesbrouck writes to me from Amsterdam that his team was “quite surprised” to discover the video entry in this year’s DiabetesMine Design Challenge on the FootSafe foot scanner, because his team believed they had no competition with this type of foot scanner.

What’s different about the Vincent 50, I’m told, is that it makes “non weight-bearing” images of the foot, so professionals can get a better view of possible damages. “See what is happening if you press your hand against a glass,” Ger writes. “It turns white, but you would like to see the red aspect.“ When the patient has to stand on the scanner, the pressure itself alters the image. Without pressure, the image shows every aspect of the foot and skin, pure and simple.

MeDaVinci already has a European patent on the technology, and patents are pending in the US and Japan, expected to be granted early 2010. My question of course was consumer price point: will the US health plans really cover such a costly home device? If not, who can afford such a fancy home scanner?

“We only see a market with high-risk patients, with poor sight and stiff joints, who already had an ulcer or minor amputation. From statistics we know that within a year 50% will develop a new problem. Preventing this problem will justify the placement of a scanner,” Ger adds.

Well, in Europe that is probably the case. But no guarantees in this country, where health care has gone from a “hairball” to a national battlefield. Nevertheless, the financial case for an ultra-sensitive home foot scanner for people with diabetic foot damage is a strong one. Consider:

* According to the International Diabetes Federation, there are over 1 million amputations worldwide each year

* Every 30 seconds, a lower limb is lost somewhere in the world as a consequence of diabetes

* The risk of amputation is a life long threat to diabetic patients; following an amputation, 30 to 50% of patients will undergo a further amputation of (or part of) the other foot within 5 years

* The diabetic foot is now one of the major problems in health care for the coming decade



If you have neuropathy, I beg you to perform those daily checks. If you don’t, and you’re lazy like me, this might be a good wake up call to start paying attention to your diabetic feet!

Wednesday, September 9, 2009

Diabetic foot team lowers rate of major amputations

Incidence of major diabetic foot amputations decreased 41% in 10 years.

By Gina Brockenbrough
ORTHOPAEDICS TODAY EUROPE 2009; 12:17
Norwegian investigators discovered a significant decrease in the incidence of diabetic foot amputations in one town 10 years after the establishment of a diabetic foot team at the city’s only hospital.

“We have registered a 41% decrease in major diabetic amputations,” Eivind Witsø, MD, said during his presentation at the 10th EFORT Congress. “The decrease reflects the improved quality of the prevention and treatment of diabetic foot ulcers and a general improvement in public health.”

In a previous study of patients with diabetes in the city of Trondheim, Norway, Witsø and his colleagues identified a rate of 4.4 lower extremity amputations per 1,000 patients each year between 1994 and 1997 — a rate he considered high.

In response, the investigators established the Trondheim Diabetic Foot Team as part of the orthopaedic surgery department at St. Olav’s University Hospital. The team consisted of an orthopaedic surgeon, nurse, podiatrist, prosthetist and orthotist, and focused on preventative care and early treatment.

The investigators compared the incidence of diabetic amputations from 1994 to 1997 with information from 2004 to 2007.


Amputations

The investigators found that the overall incidence of diabetic amputations per 1,000 patients with diabetes per year significantly decreased from 4.4 to 2.8 in 10 years.

Although they found that the incidence of minor diabetic amputations also decreased, the difference was not statistically significant.

Witsø said the study revealed no significant difference in the number of vascular interventions performed on patients with diabetes during the decade. He also noted that the diabetic foot team screened nearly 750 patients and performed nearly 6,000 consultations between 1996 and 2006.

A global trend?

During the paper discussion, co-moderator Per Kjaersgaard-Andersen, MD, asked Witsø if there has been a global decrease in the incidence of diabetic amputation.

“No, it’s not a global observation,” Witsø responded. He noted that while some countries have seen a decrease, diabetic foot amputation remains a major problem in other nations. He added that other researchers have observed a decline in diabetic amputations due to preventative care and an increase in vascular interventions.

“Perhaps this is one of the first studies that has shown a decrease in amputations that cannot be explained by an increase in vascular interventions,” Witsø said.

For more information:
Per Kjaersgaard-Andersen, MD, heads the Section for Hip and Knee Replacement, Department of Orthopaedics, Vejle Hospital, DK-7100 Vejle, Denmark; +45-7940-5716; e-mail: pka@dadlnet.dk. He has no direct financial interest in any products or companies mentioned in this article.
Eivind Witsø, MD, can be reached at St. Olav’s University Hospital, Norwegian University of Science, Gate 17, N-7006 Trondheim, Norway, 7030; +47-738-68000; e-mail: eivind.witso@stolav.no. He has no direct financial interest in any products or companies mentioned in this article.
Reference:

Eivind W, Arne L, Stian L. Forty percent decrease in the incidence of diabetic amputations in 10 years. Paper F197. Presented at the 10th EFORT Congress. June 3-6, 2009. Vienna.

Spreading the SALSA: University of Arizona's SALSA and University of Cardiff's Transatlantic Healing Collaborative Well Underway

The University of Arizona's Southern Arizona Limb Salvage Alliance (SALSA), under the direction of Professor of Surgery David G. Armstrong, DPM, PhD, continued its goal of "spreading the SALSA" in its unique collaborative with the renowned Wound Healing Research Unit at the University of Cardiff United Kingdom. The Collaborative, which has contributed to research and education, took on a new arm this week with Armstrong's lecture to Cardiff University's Masters of Science program in Tissue Repair and Wound Healing. "As a graduate of that program, it is an absolute pleasure to work with them in this capacity." noted Armstrong. "Our Universities' collective Biocommunications units are absolutely world class on both sides of the Atlantic. Telemedicine and telemedical education are now part and parcel of SALSA's mission." The MSc program, founded and run by Cardiff University's Professor Keith Harding, is the first and only Masters program of its type in the world. 






Tuesday, September 8, 2009

Heat Shock Relevant Cascade: Building the Podiatrist's Armour Against Inflammation

Providing better outcomes for patients with diabetic foot ulcers is the key to reduce the burden of traumatic amputations. Recent work from Mir et al. (2009), Christian Medical College, Vellore (India), suggests that heat shock protein 70 gene polymorphism is associated with the severity of diabetic foot ulcer. This is a remarkable concept and we at SALSA bowl feel it could be another armour in our fight against inflammation.

Wikipedia defines Heat Shock Proteins as "Heat shock proteins (HSP) are a class of functionally related proteins whose expression is increased when cells are exposed to elevated temperatures or other stress". This may be directly related to the diabetic population with lower extremity complications. It is often the repetitive stress/trauma and increased temperature that precedes an underlying ulceration.

What is amazing is that, temperature (or inflammation) is not always bad! Although, inflammation precedes an underlying ulceration, it is also an essential permissive component of the healing cascade. We at SALSA are studying temperature patterns/profiles for both pre-ulcerous patients and patients with active ulcers. We often refer to temperatures as the "Flare response" at the plantar surface. The working hypothesis is that perhaps by identifying this flare at baseline and developing a "Thermal Index" we can predict healers Vs non-healers, much on the lines of Dr. Sheehan's work regarding identifying which wounds would benefit from the expensive wound care modalities and which ones could be healed with less expensive modalities. <